To improve the accuracy and efficiency of tool wear predictions, this study proposes a tool wear prediction model called LSTM_ResNet which is based on the long short-term memory (LSTM) network and the Residual Network (ResNet). The model utilizes LSTM layers for processing, where the first block and loop blocks serve as the core modules of the deep residual network. The model employs a series of methods including convolution, batch normalization (BN), and Rectified Linear Unit (ReLU) to enhance the model’s expression and prediction capabilities. The performance of the LSTM_ResNet model was evaluated using experimental data from the PHM2010 datasets and two different depths (64 and 128 layers), training both LSTM_ResNet models for 200 epochs. The 64-layer model’s root mean square error (RMSE) values are 3.36, 4.35, and 3.59, and the mean absolute error (MAE) values are 2.42, 2.85, and 2.21; using 128 layers, the RMSE values are 3.66, 3.99, and 3.77, and the MAE values are 2.49, 2.73, and 3.01. The results indicate that the 64-layer LSTM has smaller average errors, suggesting that compared to other common network structures, the LSTM_ResNet network has a higher performance. This research provides an effective solution for tool wear prediction and helps to improve the technical level of tool wear prediction in China.