A database of six eukaryotic hypothetical genes and proteins

Abstract

Assigning functions to proteins of unknown function is of considerable interest to the proteomic researchers as the genes encoding them are conserved over various species. Here, we describe HypoDB, a database of hypothetical genes and proteins in six eukaryotes. The database was collected and organized based on the number of entries in each chromosome with few annotations. Hypothetical protein database contains information related to gene and protein sequences, chromosome number and location, secondary and tertiary structure related data.AvailabilityThe database is available for free at http://www.trimslabs.com/database/hypodb/index.html

Research Article The use of bioinformatics tools to characterize a hypothetical protein from <i>Penicillium</i> <i>rubens</i>

“…Nowadays, in silico functional studies have an important role in protein function prediction linking a hypothetical protein to one or many cellular processes and helping to elucidate its role in metabolic pathways (Ijaq et al, 2019). HPs characterization has become an attractive subject of study due to its potential importance, leading to creation of some databases where only HPs sequences are described, such as HypoDB (Adinarayana et al, 2011).…”

In silicofunctional and tumor suppressor role of hypothetical protein PCNXL2 with regulation of the Notch signaling pathway

“…1 The sequences of these proteins are known, but no experimental studies have been conducted to explore their functions. This is due to the fact that the proteins are predicted using computational methods, which rely on signals in DNA sequences to predict them as genes or based on their similarity to genes in other organisms.…”

“…Although the genome sequences of many organisms are available in databases, there are some proteins whose functions are unknown; it is necessary to functionally characterize these proteins, which are known as hypothetical proteins. 1 The sequences of these proteins are known, but no experimental studies have been conducted to explore their functions. This is due to the fact that the proteins are predicted using computational methods, which rely on signals in DNA sequences to predict them as genes or based on their similarity to genes in other organisms.…”

In-silico Structural and Functional Analysis of Hypothetical Proteins of Leptospira Interrogans

“…Genome sequencing projects and genetic engineering has revealed many aspects of complex cellular environment containing large number of proteins. Despite sequences of most of organisms are available and proteins coded are studied experimentally, there are some proteins whose functions are unknown, need to be characterised [1]. Such proteins are known as Hypothetical Proteins (HP) sequences [2] of which are known but there is no evidence of experimental study [3].…”