A Decade of Advancements in Pauson–Khand‐Type Reactions

Abstract

This Microreview illustrates the conceptual evolution of Pauson-Khand-type reactions and the recent advancements in catalyst design and applications. Intra-and intermolecular Pauson-Khand-type reactions, as well as their enantioselec-

Integration of CO2 Reduction with Subsequent Carbonylation: Towards Extending Chemical Utilization of CO2

“…20 mL, 0.892 mmol), 130 8C, 24 h; chamber Bw as loadedw ith PdCl 2 (5 mol %, 0.0045 g), Xantphos( 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene) ( Recently,t he CO-gas-free version of the Pauson-Khand reaction has become ap romisingf ieldf or the constructiono fc yclopentenones and their derivatives. [42,43] The combination of reduction of CO 2 to CO and rhodium(I)-catalyzed Pauson-Khand-type reactionw as provedf easible, delivering the diester-linked and oxygen-tethered products 4f and 4g in 36 % and 41 %y ields, respectively (Scheme 4).…”

Radical Mediated Aza‐Pauson‐Khand Reaction of Acetylenes, Imines, and CO Leading to Five‐Membered Unsaturated Lactams

“…The overall transformation represents a radical-mediated aza-Pauson-Khand reaction. [29,30] In this article, we report the results on the extension of [2 + 2 + 1] cycloaddition reaction with a variety of aromatic imines as coupling partner, leading to fivemembered unsaturated lactams, whose structure are often found in biologically active molecules (Scheme 2, Eqn. 2).…”

Rh(I)-catalyzed intramolecular [2 + 2 + 1] cycloaddition of allenenes: Construction of bicyclo[4.3.0]nonenones with an angular methyl group and tricyclo[6.4.0.01,5]dodecenone

“…The intramolecular PKR [3–9] provides a powerful method for the construction of bicyclo[3.3.0]oct-1-en-3-one and bicyclo[4.3.0]non-1(9)-en-8-one frameworks. In contrast to the fact that the 2-alkyl (or phenyl)-1-hepten-6-ynes also efficiently afford 5-alkyl (or phenyl)bicyclo[3.3.0]oct-1-en-3-ones [10–19], the one-methylene homologated substrates furnish the corresponding bicyclo[4.3.0] skeletons with an angular substituent in rather lower yields [20–22].…”