A Decade of Invasive Meningococcal Disease Surveillance in Poland

Skoczyńska, Anna; Waśko, Izabela; Kuch, Alicja; Kadłubowski, Marcin; Gołębiewska, Agnieszka; Foryś, Małgorzata; Markowska, Marlena; Ronkiewicz, Patrycja; Wasiak, Katarzyna; Kozińska, Aleksandra; Matynia, B.; Hryniewicz, Waleria

doi:10.1371/journal.pone.0071943

Cited by 39 publications

(38 citation statements)

References 45 publications

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“…N. meningitidis is most likely to cause meningitis in children and adolescents and has a mortality rate of 10.1% in the United States (14). The serotypes most commonly implicated are A, B, C, W135, and Y (14,(36)(37)(38), and meningitis without shock is the most common presentation (38). The predominant clinical feature, which can distinguish N. meningitidis from other causes of bacterial meningitis, is the presence of a petechial rash.…”

Section: Meningitismentioning

confidence: 99%

Pathogens Penetrating the Central Nervous System: Infection Pathways and the Cellular and Molecular Mechanisms of Invasion

et al. 2014

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SUMMARY The brain is well protected against microbial invasion by cellular barriers, such as the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB). In addition, cells within the central nervous system (CNS) are capable of producing an immune response against invading pathogens. Nonetheless, a range of pathogenic microbes make their way to the CNS, and the resulting infections can cause significant morbidity and mortality. Bacteria, amoebae, fungi, and viruses are capable of CNS invasion, with the latter using axonal transport as a common route of infection. In this review, we compare the mechanisms by which bacterial pathogens reach the CNS and infect the brain. In particular, we focus on recent data regarding mechanisms of bacterial translocation from the nasal mucosa to the brain, which represents a little explored pathway of bacterial invasion but has been proposed as being particularly important in explaining how infection with Burkholderia pseudomallei can result in melioidosis encephalomyelitis.

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Section: Meningitismentioning

confidence: 99%

Pathogens Penetrating the Central Nervous System: Infection Pathways and the Cellular and Molecular Mechanisms of Invasion

et al. 2014

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“…In Poland, cases of IPD are identified through two independent surveillance systems, a hospital-based surveillance system run by the National Institute of Public Health-National Institute of Hygiene (NIPH-NIH) and a laboratory-confirmed surveillance system performed in the National Reference Centre for Bacterial Meningitis (NRCBM), described elsewhere [11,12]. The latter system provides phenotypic and genotypic characteristics of isolates, together with epidemiological data.…”

Section: Introductionmentioning

confidence: 99%

Recent trends in epidemiology of invasive pneumococcal disease in Poland

Skoczyńska

Kuch

Sadowy

et al. 2014

Eur J Clin Microbiol Infect Dis

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The objectives of this study were to assess the current incidence of invasive pneumococcal disease (IPD) in Poland (2011-2013), where mass vaccination has not been implemented, and to characterize the Streptococcus pneumoniae isolates responsible for invasive infections by determining their serotype distribution and antimicrobial resistance patterns. For all isolates identification, serotyping and antimicrobial minimal inhibitory concentrations determination were performed based on routine techniques. The highest incidence rates were observed among adults older than 85 years old (4.62/100,000) and children under 1 year of age (4.28/100,000). The general case fatality ratio (CFR) was 25.4%, with the highest CFR in the age group ≥85 years old (59.7%). The most common serotypes were 3, 14, 19A, 4, 9V, 19F, 1, and 23 F (61.3% of all isolates). The 10- and 13-valent pneumococcal conjugated vaccines (PCV) covered 46.0 and 71.8% of all IPD cases, 61.4 and 79.5% of cases in children under two years, and 60.4 and 78.6% of cases involving children under five years of age, respectively. The PCV13 and 23-valent polysaccharide vaccine covered 68.7 and 86.0% of cases in adults >65 years old, respectively. Decreased susceptibility was noted for penicillin (24.8%), cefotaxime (10.0%), meropenem (5.0%), rifampicin (0.8%), chloramphenicol (4.3%), erythromycin (29.7%) and clindamycin (25.6%). Multi-drug resistance characterized 21.6% of the pneumococci tested. Despite deficiencies in the Polish surveillance system and strong underestimation of IPD cases, results of the study showed good theoretical coverage of PCV, which should encourage inclusion of anti-pneumococcal conjugate vaccine into the national immunization program.

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“…Serogroup B is responsible for most of the cases of meningococcal infection also in Poland, as reported in the study conducted by Skoczyń ska et al [65].…”

Section: Europementioning

confidence: 69%

“…Serogroups B, together with serogroup C, is responsible for most of the cases of infection in the industrialized countries of Europe, Australia and Americas [6,[61][62][63][64][65][66]. Serogroup B strains able to promote IMD are characterized by strong genetic differences compared with other serogroups.…”

Section: Epidemiology Of Serogroup B Meningococcal Diseasementioning

confidence: 99%

Neisseria meningitidisinfection: who, when and where?

Gianchecchi

Torelli

Piccini

et al. 2015

Expert Review of Anti-infective Therapy

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Neisseria meningitidis is a Gram-negative β-proteobacterium responsible for an endemic worldwide infection. The epidemiology and serogroup distribution can change very quickly. The incidence of meningitis infection varies from very rare to more than 1000 cases per 100,000 of the population yearly. The carriage of N. meningitidis, which represents an exclusive human commensal, is asymptomatic, but in rare cases bacteria proliferate in the CNS and rapidly lead to the death of the affected subjects. Host genetic factors, such as single nucleotide polymorphisms, can promote meningococcal disease, being able to influence the individual predisposition to the pathology. Although a reduction in meningococcal disease has been observed in Europe, a continuous surveillance is necessary to control any possible outbreaks of new hypervirulent clones into populations that could modify the epidemiology of meningococcal infections and the clinical spectrum of affected subjects.

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A Decade of Invasive Meningococcal Disease Surveillance in Poland

Cited by 39 publications

References 45 publications

Pathogens Penetrating the Central Nervous System: Infection Pathways and the Cellular and Molecular Mechanisms of Invasion

Pathogens Penetrating the Central Nervous System: Infection Pathways and the Cellular and Molecular Mechanisms of Invasion

Recent trends in epidemiology of invasive pneumococcal disease in Poland

Neisseria meningitidisinfection: who, when and where?

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