A decade of test-retest reliability of functional connectivity: A systematic review and meta-analysis

Noble, Stephanie; Scheinost, Dustin; Constable, R. Todd

doi:10.1016/j.neuroimage.2019.116157

Cited by 478 publications

(496 citation statements)

References 130 publications

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“…To enable the inclusion of a greater number of individuals with the rare condition ICA, data was collected at two different locations. The use of multiple sites has been reported to have minimal effects on the reliability of functional connectivity, but uncontrolled differences across sites may potentially introduce bias (Noble et al 2019). Thus, efforts were made to minimize the effects of scanning site: 3T Siemens scanners with identical scanning sequence protocols were used at both sites, site was included as a nuisance covariate in the analyses, and importantly, the matched control was always scanned at the same site as the individual with ICA, thus preventing inter-group effects of scanning site.…”

Section: Discussionmentioning

confidence: 99%

Normal Olfactory Functional Connectivity Despite Life-Long Absence of Olfactory Experiences

Peter

Fransson

Mårtensson

et al. 2020

Preprint

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Congenital blindness is associated with atypical morphology, and functional connectivity within and from, visual cortical regions; changes that are hypothesized to originate from a life-long absence of visual input and could be regarded as a general (re)organization principle of sensory cortices. Challenging this is the fact that individuals with congenital anosmia (life-long olfactory sensory loss) display little to no morphological changes in primary olfactory cortex. To determine whether olfactory input from birth is essential to establish and maintain normal functional connectivity in olfactory processing regions, akin to the visual system, we assessed differences in functional connectivity within olfactory cortex between individuals with congenital anosmia (n=33) and matched controls (n=34). Specifically, we assessed differences in connectivity between core olfactory processing regions as well as differences in regional homogeneity and homotopic connectivity within primary olfactory cortex. In contrast to congenital blindness, none of the analyses indicated atypical connectivity in individuals with congenital anosmia. In fact, post-hoc Bayesian analysis provided support for an absence of group differences. These results suggest that a lifelong absence of olfactory experience has limited impact on the functional connectivity in olfactory cortex, a finding that indicates a clear difference between sensory modalities in how sensory cortical regions develop.

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Section: Discussionmentioning

confidence: 99%

Normal Olfactory Functional Connectivity Despite Life-Long Absence of Olfactory Experiences

Peter

Fransson

Mårtensson

et al. 2020

Preprint

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“…Particularly, the latest study by Burr et al (2020) used the largest sample up to date (N = 1316) in a data-driven, theory-free approach and found that intrinsic connectivity of the default mode network was associated with dispositional use of suppression (but not reappraisal). Critically, the authors used general functional connectivity (GFC, Elliott et al, 2019) to leverage shared features of task and resting-state fMRI and circumvent reported reliability issues of resting state measures (e.g., Noble, Scheinost, & Constable, 2019) . Thus, instead of focusing on connectivity in a priori regions of interest between cortical and subcortical areas, distributed networks of brain regions might be a more promising target in future studies as they take into account the complexity of the underlying neuronal processes.…”

Section: Discussionmentioning

confidence: 99%

Resting state cortico-limbic functional connectivity and dispositional use of emotion regulation strategies: A replication and extension study

Dörfel¹,

Gärtner²,

Scheffel³

2020

Preprint

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Neuroimaging functional connectivity analyses have shown that the negative coupling between amygdala and cortical regions is linked to better emotion regulation (ER) in experimental task settings. However, less is known about the neural correlates of ER traits or dispositions. The present study aimed to (1) replicate the findings of differential cortico-limbic coupling during resting state depending on the dispositional use of ER strategies. Furthermore, the study aimed to (2) extend prior findings by examining whether differences in cortico-limbic coupling during resting state predict behavioral and neuronal emotion regulation success in a standard emotion regulation task. To this end, N=107 healthy adults completed the Emotion Regulation Questionnaire (ERQ), underwent an 8-min resting-state fMRI acquisition and completed a reappraisal task during fMRI. Functional connectivity maps of basolateral and centromedial amygdala nuclei were estimated with a seed-based approach regarding associations with regions of the prefrontal cortex, and were then correlated with ERQ scores as well as behavioral and neuronal ER success. All hypotheses and the analysis plan are preregistered at https://osf.io/8wsgu. Opposed to prior findings, we were not able to replicate a correlation of habitual ER strategy use with functional connectivity between amygdala and PFC regions (p > 0.05, FWE-corrected). Furthermore, there was no association of behavioral and neuronal reappraisal success with functional connectivity between amygdala and insula as well as PFC (p > 0.05, FWE-corrected). The present preregistered study calls into question the reported association between individual differences in resting state cortico-limbic connectivity and habitual use of ER strategies. However, ongoing advances in functional brain imaging and distributed network approaches may leverage the identification of reliable functional connectivity patterns that underlie successful emotion regulation.

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“…Test-retest reliability is often used as a measure for reproducibility and generalizability. Although graph measures, such as global efficiency and Gcc, show fair-to-good testretest reliability (Welton et al 2015), a recent meta-analysis showed that edges within a functional connectivity matrix -on the basis of which graph measures are calculated -show poor test-retest reliability (Noble et al 2019). This low test-retest reliability influences statistical power and necessitates the inclusion of larger samples to reach the effect size of interest (Matheson 2019;Zuo et al 2019).…”

Section: Discussionmentioning

confidence: 99%

“…This low test-retest reliability influences statistical power and necessitates the inclusion of larger samples to reach the effect size of interest (Matheson 2019;Zuo et al 2019). It is, however, important to note that test-retest reliability is not the same as validity and the meta-analysis showed that one of the main factors that influenced test-retest reliability was artefact correction (Noble et al 2019); a necessary step during preprocessing to remove motion and other non-neural physiological noise from the data and avoid spurious results (Parkes et al 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, although absolute values of intra-individual edges show low reproducibility (Noble et al 2019), inter-individual differences in the functional connectome are stable across, days, months and even years (Horien et al 2019;Finn et al 2015;Miranda-Dominguez et al 2014), and its characteristics are uniquely associated with a particular individual across time (Horien et al 2019).…”

Section: Discussionmentioning

confidence: 99%

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Resting-state network topology and planning ability in healthy adults

Vriend

Wagenmakers

Heuvel

et al. 2019

Preprint

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Functional magnetic resonance imaging (fMRI) studies have been used extensively to investigate the brain areas that are recruited during the Tower of London (ToL) task. Nevertheless, little research has been devoted to study the neural correlates of the ToL task using a network approach. Here we investigated the association between functional connectivity and network topology during restingstate fMRI and ToL task performance, that was performed outside the scanner. Sixty-two (62) healthy subjects (21-74 years) underwent eyes-closed rsfMRI and performed the task on a laptop. We studied global (whole-brain) and within subnetwork resting-state topology as well as functional connectivity between subnetworks, with a focus on the default-mode, fronto-parietal and dorsal and ventral attention networks. Efficiency and clustering coefficient were calculated to measure network integration and segregation, respectively, at both the global and subnetwork level. Our main finding was that higher global efficiency was associated with slower performance (β = .22, Pbca = .04) and this association seemed mainly driven by inter-individual differences in default-mode network connectivity. The reported results were independent from age, sex, education-level and motion.Although this finding is contrary to earlier findings on general cognition, we tentatively hypothesize that the reported association may indicate that individuals with a more integrated brain during the resting-state are less able to further increase network efficiency when transitioning from a rest to task state, leading to slower responses. This study also adds to a growing body of literature supporting a central role for the default-mode network in individual differences in cognitive performance.

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A decade of test-retest reliability of functional connectivity: A systematic review and meta-analysis

Cited by 478 publications

References 130 publications

Normal Olfactory Functional Connectivity Despite Life-Long Absence of Olfactory Experiences

Normal Olfactory Functional Connectivity Despite Life-Long Absence of Olfactory Experiences

Resting state cortico-limbic functional connectivity and dispositional use of emotion regulation strategies: A replication and extension study

Resting-state network topology and planning ability in healthy adults

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