A Decennium of Etiology and Antimicrobial Susceptibility Patterns in Patients with Infective Endocarditis at a University Hospital, Thailand

Nakaranurack, Chotirat; Puttilerpong, Chankit; Suwanpimolkul, Gompol

doi:10.7883/yoken.jjid.2016.294

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…It was associated with the "defense response to other organism", "defense response", "defense response to virus" and "cytokine-mediated signaling pathway" ontological groups. In a 2016 study, IFIT1 was shown to be upregulated during the early antral follicle to small antral follicle transition in vivo, but was downregulated between early antral follicles and in vitro cultures of GC and oocyte complexes, highlighting it as an important determinant in the differences between in vivo and in vitro cultures' gene expression profiles [30]. Furthermore, the next of the genes, major histocompatibility complex Class II, DP alpha 1 (HLA-DPA1), was upregulated 24.10-fold.…”

Section: Discussionmentioning

confidence: 99%

Expression Profile of New Gene Markers and Signaling Pathways Involved in Immunological Processes in Human Cumulus-Oophorus Cells

Chermuła

Hutchings

Kranc

et al. 2021

Genes

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The function of the immune system extends from defense against external pathogens to the recognition and elimination of mutated or dying cells, aiding elimination of malignant potential and/or maintaining homeostasis. The many cell types of the immune system secrete a broad range of factors to enable cellular signaling that is vital to physiological processes. Additionally, in the ovary, follicular selection and maturation, as well as ovulation, are directly regulated by the nearby immune cells. Additionally, ovulation and rupture of the follicle have been observed to resemble a local inflammatory response. Cells of the cumulus–oocyte complex (COC) show evolving gene expression profiles throughout the oocytes’ lifespan, including genes associated with immunological processes. Analysis of these genes allows the identification of useful molecular markers, as well as highlighting gene functions and interactions in these cells. Cumulus cells were obtained from hormonally stimulated patients undergoing an in vitro fertilization procedure and studied under long-term culture conditions. The microarray technique made it possible to compare the level of CCs’ gene expression on the 1st, 7th, 15th and 30th day of cultivation. Additionally, RNA microarray analysis was performed to map gene expression in these cells, associated with immunological processes and associated cytokine signaling. Subsequently, the use of DAVID software allowed us to identify the “defense response to other organism”, “defense response”, “defense response to virus”, “cytokine secretion”, “cytokine production” and “cytokine-mediated signaling pathway” GO BP terms, as well as allowing further analysis of the most differentially expressed genes associated with these processes. Of the 122 genes involved, 121 were upregulated and only one was downregulated. The seven most upregulated genes related to the abovementioned terms were ANXA3, IFIT1, HLA-DPA1, MX1, KRT8, HLA-DRA and KRT18. Therefore, genes involved in immunological defense processes are upregulated in CC cultures and could serve as useful molecular markers of growth and development in the COC, as well as the proliferation of granulosa and cumulus cells.

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Section: Discussionmentioning

confidence: 99%

Expression Profile of New Gene Markers and Signaling Pathways Involved in Immunological Processes in Human Cumulus-Oophorus Cells

Chermuła

Hutchings

Kranc

et al. 2021

Genes

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“…Other studies have revealed that Thai S. suis isolates were susceptible to penicillin [13]. This contrasted with Nakaranurack et al (2017), who reported that 6 out of 11 Thai S. suis isolates were intermediately resistance to penicillin, whereas cefotaxime and vancomycin were completely susceptible [35]. However, a study in 2021 demonstrated that 448 S. suis isolates recovered from human infections in Thailand had 8.2% intermediate resistance to penicillin, while they were all susceptible to cefepime and ceftriaxone [76].…”

Section: Antimicrobial Susceptibilitymentioning

confidence: 94%

Human Streptococcus suis Infections in Thailand: Epidemiology, Clinical Features, Genotypes, and Susceptibility

Kerdsin

2022

TropicalMed

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Streptococcus suis is a zoonotic pathogen causing substantial economic losses to the pig industry, as well as being a human health burden due to infections worldwide, especially in Southeast Asia. In Thailand, there was high cumulative incidence in humans during 1987–2021, mostly in males. At least five large outbreaks have been documented after the largest outbreak in China in 2005, which was related to the consumption of raw pork or dishes containing pig’s blood. The major clinical features are sepsis or meningitis, with hearing loss a major complication of S. suis disease. Thai human S. suis isolates have shown diversity in serotypes and sequence types (STs), with serotype 2 and STs 1 and 104 being major genotypes. β-Lactam antibiotics can be used in empirical treatment for human S. suis infections; however, intermediate resistance to penicillin has been reported. Reducing S. suis incidence in Thailand requires a multidimensional approach, with combined efforts from the government and public health sectors through policy, regulations, education, and active surveillance.

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Enterococcus Faecalis Endocarditis: What’s Next?

2020

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Enterococcus faecalis infective endocarditis (EFIE) is a complex entity in rapid evolution. Although largely relevant findings from recent studies have advanced the knowledge on EFIE and led to some changes in clinical guidelines, there are still a number of gaps to be filled. Coordinated, international, multicenter efforts are needed to obtain quality data that rend the health systems and scientific community prepared enough to understand and handle this infection. In this Perspective, some of the most relevant aspects concerning the epidemiology, clinical presentation and outcomes, diagnostic approaches and antibiotic therapy of EFIE are addressed. Also, several potential future clinical developments in the field are discussed.

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A Decennium of Etiology and Antimicrobial Susceptibility Patterns in Patients with Infective Endocarditis at a University Hospital, Thailand

Cited by 3 publications

References 24 publications

Expression Profile of New Gene Markers and Signaling Pathways Involved in Immunological Processes in Human Cumulus-Oophorus Cells

Expression Profile of New Gene Markers and Signaling Pathways Involved in Immunological Processes in Human Cumulus-Oophorus Cells

Human Streptococcus suis Infections in Thailand: Epidemiology, Clinical Features, Genotypes, and Susceptibility

Enterococcus Faecalis Endocarditis: What’s Next?

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