COVID-19 is highly efficient for port operation, and it is crucial to improve the port epidemic's emergency prevention and control capability. Therefore, according to the port operation process, the process of epidemic transmission in the port is analyzed, and the relationship map of port epidemic transmission is clarified; then, with the help of OODA theory, the OODA model of port epidemic emergency prevention and control is constructed. Through the analysis of the model operation cycle process, this paper summarizes the advantages of the model in port epidemic prevention and control. OODA port emergency prevention and control model can better improve the ability and efficiency of port epidemic emergency prevention and control.