The management and development of human resources have become one of the core contents of enterprise operation and management. At rst, it can only be used as an auxiliary tool in human resources business management, then it can develop various personnel transaction processing subsystems with relatively independent modules and perfect functions, and then realize the integration of various subsystems, Form a relatively complete set of human resource information management system. In recent years, with the rapid development of data mining technology, more and more enterprises begin to pay attention to the completion of various decision-making activities in management through the assistance of computer information systems. This paper designs an enterprise human resources decision support system based on data mining, which can more effectively support human resources management business informatization, data standardization, intelligent decision analysis, optimize human resources business process, improve human resources management business e ciency, provide more effective decision support for enterprise management and promote enterprise development.