2012
DOI: 10.1016/j.lungcan.2012.09.012
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A decrease in lung cancer mortality following the introduction of low-dose chest CT screening in Hitachi, Japan

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Cited by 48 publications
(29 citation statements)
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“…A useful paradigm would be to use the integrated DNA repair OMA score as a means to improve selection criteria for LD-CT screening for early detection of lung cancer, by identifying individuals at extra-high risk. Pending validation, such a strategy is expected to significantly increase the rate of true-positives, thereby avoiding unnecessary invasive procedures and improving cost-benefit (42)(43)(44). In addition, having the OMA personalized measure for DNA repair activity raises the possibility of searching for drugs that will improve the effectiveness of DNA repair, potentially providing protection against lung cancer.…”
Section: Discussionmentioning
confidence: 99%
“…A useful paradigm would be to use the integrated DNA repair OMA score as a means to improve selection criteria for LD-CT screening for early detection of lung cancer, by identifying individuals at extra-high risk. Pending validation, such a strategy is expected to significantly increase the rate of true-positives, thereby avoiding unnecessary invasive procedures and improving cost-benefit (42)(43)(44). In addition, having the OMA personalized measure for DNA repair activity raises the possibility of searching for drugs that will improve the effectiveness of DNA repair, potentially providing protection against lung cancer.…”
Section: Discussionmentioning
confidence: 99%
“…For men and women ages 50-79, lung cancer mortality fell by 24%. (23) The Japanese approach to screening non-smokers and smokers alike was successful in demonstrating that its model may reduce lung cancer deaths among non-smokers, considering that more than half of the study participants were non-smokers and 60% of screen-detected cancers were found in non-smokers. The group surmised that an observed reduction in lung cancer mortality among Hitachi residents was due, at least in part, to the effect of CT screening on lung cancer mortality among non-smokers.…”
Section: International Lung Screening Guidelines and Trialsmentioning
confidence: 99%
“…Although presently limited to Japan, results suggest that wide implementation of low-dose chest computed tomography screening may decrease lung cancer mortality[103]. …”
Section: Cancer Screeningmentioning
confidence: 99%