“…As well as this, manual annotation makes it difficult to generate large-scale datasets for segmentation tasks in computational pathology. Iterative labelling strategies (Tavolara et al, 2020;Graham et al, 2021a;Jaber et al, 2021), which use a human-in-theloop mechanism, have recently been used in the literature and can help significantly decrease the time required for annotation, while still ensuring a high level of accuracy.…”