A deep learning model combining multimodal radiomics, clinical and imaging features for differentiating ocular adnexal lymphoma from idiopathic orbital inflammation

Xie, Xiaoyang; Yang, Lijuan; Zhao, Fengjun; Wang, Dong; Zhang, Hui; He, Xuelei; Cao, Xin; Yi, Huangjian; He, Xiaowei; Hou, Yi

doi:10.1007/s00330-022-08857-6

Cited by 23 publications

(8 citation statements)

References 50 publications

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“…A previous study used T1WI, T1WI-T1CE, and T1WI-T1CE-T2WI for radiomics analysis and achieved AUCs of .722, .795, and .843, respectively. 30 Consistent with our findings, they found that the multimodal MRI-based model outperformed the bimodal and unimodal models potentially since multimodal or multi-parametric learning can aggregate information from multiple sources. With sufficient training data, the richer the modalities or parameters input, the more accurate the estimation of the representation space that can be achieved.…”

Section: Discussionsupporting

confidence: 91%

Peritumoural Radiomics for Identification of Telomerase Reverse Transcriptase Promoter Mutation in Patients With Glioblastoma Based on Preoperative MRI

et al. 2023

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Purpose: To evaluate the value of intra- and peritumoral deep learning (DL) features based on multi-parametric magnetic resonance imaging (MRI) for identifying telomerase reverse transcriptase (TERT) promoter mutation in glioblastoma (GBM). Methods: In this study, we included 229 patients with GBM who underwent preoperative MRI in two hospitals between November 2016 and September 2022. We used four 2D Convolutional Neural Networks (GoogLeNet, DenseNet121, VGG16, and MobileNetV3-Large) to extract intra- and peritumoral DL features. The Mann–Whitney U test, Pearson correlation analysis, least absolute shrinkage and selection operator, and logistic regression analysis were used for feature selection and construction of DL radiomics (DLR) signatures in different regions. These multi-parametric and multi-region signatures were combined to identify TERT promoter mutation. The area under the receiver operating characteristic curve (AUC) was used to evaluate the effects of the signatures. Results: The signatures based on the DL features from the peritumoral regions with expansion distances of 2 mm, 8 mm, and 10 mm using the GoogLeNet architecture correlated with the optimal AUC values (test set: .823, .753, and .768) in the T2-weighted, T1-weighted contrast-enhanced, and T1-weighted images. Using the stacking fusion method, DLR with multi-parameter and multi-region fusion achieved the best discrimination with AUC values of .948 and .902 in the training and test sets, respectively. Conclusions: The radiomics model based on the fusion of multi-parameter MRI intra- and peritumoral DLR signatures may help to identify TERT promoter mutation in patients with GBM.

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Section: Discussionsupporting

confidence: 91%

Peritumoural Radiomics for Identification of Telomerase Reverse Transcriptase Promoter Mutation in Patients With Glioblastoma Based on Preoperative MRI

et al. 2023

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“…DLR has emerged in recent years. The DLR method showed good performance in predicting axillary lymph-node metastasis in early-stage breast cancer ( 27 ) and in identifying ocular adnexal lymphoma and idiopathic orbital inflammation ( 28 ). In addition, it has been successfully used in ultrasonography to predict the pCR of breast cancer to NAC ( 29 , 30 ).…”

Section: Discussionmentioning

confidence: 99%

Deep learning radiomic analysis of DCE-MRI combined with clinical characteristics predicts pathological complete response to neoadjuvant chemotherapy in breast cancer

Fan²,

Xu³

et al. 2023

Front. Oncol.

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ObjectiveThe aim of this study was to develop and validate a deep learning-based radiomic (DLR) model combined with clinical characteristics for predicting pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer. For early prediction of pCR, the DLR model was based on pre-treatment and early treatment dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data.Materials and methodsThis retrospective study included 95 women (mean age, 48.1 years; range, 29–77 years) who underwent DCE-MRI before (pre-treatment) and after two or three cycles of NAC (early treatment) from 2018 to 2021. The patients in this study were randomly divided into a training cohort (n=67) and a validation cohort (n=28) at a ratio of 7:3. Deep learning and handcrafted features were extracted from pre- and early treatment DCE-MRI contoured lesions. These features contribute to the construction of radiomic signature RS1 and RS2 representing information from different periods. Mutual information and least absolute shrinkage and selection operator regression were used for feature selection. A combined model was then developed based on the DCE-MRI features and clinical characteristics. The performance of the models was assessed using the area under the receiver operating characteristic curve (AUC) and compared using the DeLong test.ResultsThe overall pCR rate was 25.3% (24/95). One radiomic feature and three deep learning features in RS1, five radiomic features and 11 deep learning features in RS2, and five clinical characteristics remained in the feature selection. The performance of the DLR model combining pre- and early treatment information (AUC=0.900) was better than that of RS1 (AUC=0.644, P=0.068) and slightly higher that of RS2 (AUC=0.888, P=0.604) in the validation cohort. The combined model including pre- and early treatment information and clinical characteristics showed the best ability with an AUC of 0.925 in the validation cohort.ConclusionThe combined model integrating pre-treatment, early treatment DCE-MRI data, and clinical characteristics showed good performance in predicting pCR to NAC in patients with breast cancer. Early treatment DCE-MRI and clinical characteristics may play an important role in evaluating the outcomes of NAC by predicting pCR.

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“…The AI system was validated, showing an accuracy greater than 0.900 on a multicenter database. Xie et al (2022) developed a DL model that combines multimodal radiomics with clinical and imaging features to distinguish ocular adnexal lymphoma (OAL) from idiopathic orbital inflammation (IOI). The diagnosing results yielded an AUC of 0.953, indicating that the DL-based analysis may successfully help distinguish between OAL and IOI.…”

Section: Sabatesmentioning

confidence: 99%

Orbital and eyelid diseases: The next breakthrough in artificial intelligence?

Bao

Sun

Zhan

et al. 2022

Front. Cell Dev. Biol.

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Orbital and eyelid disorders affect normal visual functions and facial appearance, and precise oculoplastic and reconstructive surgeries are crucial. Artificial intelligence (AI) network models exhibit a remarkable ability to analyze large sets of medical images to locate lesions. Currently, AI-based technology can automatically diagnose and grade orbital and eyelid diseases, such as thyroid-associated ophthalmopathy (TAO), as well as measure eyelid morphological parameters based on external ocular photographs to assist surgical strategies. The various types of imaging data for orbital and eyelid diseases provide a large amount of training data for network models, which might be the next breakthrough in AI-related research. This paper retrospectively summarizes different imaging data aspects addressed in AI-related research on orbital and eyelid diseases, and discusses the advantages and limitations of this research field.

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A deep learning model combining multimodal radiomics, clinical and imaging features for differentiating ocular adnexal lymphoma from idiopathic orbital inflammation

Cited by 23 publications

References 50 publications

Peritumoural Radiomics for Identification of Telomerase Reverse Transcriptase Promoter Mutation in Patients With Glioblastoma Based on Preoperative MRI

Peritumoural Radiomics for Identification of Telomerase Reverse Transcriptase Promoter Mutation in Patients With Glioblastoma Based on Preoperative MRI

Deep learning radiomic analysis of DCE-MRI combined with clinical characteristics predicts pathological complete response to neoadjuvant chemotherapy in breast cancer

Orbital and eyelid diseases: The next breakthrough in artificial intelligence?

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