A Delayed Cerebral Vasospasm with Infarction Is Secondary to &lt;i&gt;Listeria monocytogenes&lt;/i&gt; Meningitis: MRI and MRA Are Diagnostically Useful

Kobayashi, Toshiyuki; Tadokoro, Hiroshi; Odai, Tsuyoshi; Hibino, Takenori; Waki, Kanami

doi:10.2169/internalmedicine.54.5010

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…Cerebral hemorrhage is the most common type of cerebrovascular disease in humans (accounting for 20–30%) and the least treatable subtype of hemorrhagic stroke (mortality rate, 30–40%) ( 1 ). The most common manifestations in the clinic are cerebral arteriosclerosis, hypertension and intracranial vascular malformations ( 2 ). Cerebral hemorrhage is often induced by exertion and emotions, and most patients show sudden onset during activity.…”

Section: Introductionmentioning

confidence: 99%

Anti‑inflammatory effects of Simvastatin in patients with acute intracerebral hemorrhage in an intensive care unit

et al. 2017

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Intracerebral hemorrhage is one of the most common types of cerebrovascular disease in humans and often causes paralysis, a vegetative state and even death. Patients with acute intracerebral hemorrhage are frequently monitored in intensive care units (ICUs). Spontaneous intracerebral hemorrhage is associated with a higher rate of mortality and morbidity than other intracephalic diseases. The expression levels of inflammatory factors have important roles in inflammatory responses indicative of changes in a patient's condition and are therefore important in the monitoring and treatment of affected patients at the ICU as well as the development of therapeutic strategies for acute cerebral hemorrhage. The present study investigated the anti-inflammatory effects of Simvastatin in patients with acute intracerebral hemorrhage at an ICU, and inflammatory factors and cellular changes were systematically analyzed. The plasma concentrations of inflammatory factors, including interleukin (IL)-4, IL-6, IL-8 and IL-10, were evaluated by ELISAs. The plasma concentrations of inflammatory cellular changes were detected by using flow cytometry. The results demonstrated that after Simvastatin treatment of patients with acute cerebral hemorrhage at the ICU, the plasma concentrations of IL-4, IL-6, IL-8 and IL-10 were downregulated compared with those in placebo-treated controls. In addition, Simvastatin treatment at the ICU decreased lymphocytes, granulocytes and mononuclear cells in patients with acute cerebral hemorrhage. The levels of inflammatory factors were associated with brain edema in patients with acute cerebral hemorrhage treated at the ICU. In addition, the amount of bleeding was reduced in parallel with the inflammatory cell plasma concentration of lymphocytes, granulocytes and mononuclear cells. Importantly, Simvastatin treatment produced beneficial outcomes by improving brain edema and reducing the amount of bleeding. In conclusion, the present study demonstrated the efficacy of Simvastatin in treating acute intracerebral hemorrhage and evidenced the association between inflammatory responses and the progress of affected patients at the ICU, thereby providing insight for applying effective therapies for patients with acute intracerebral hemorrhage.

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Section: Introductionmentioning

confidence: 99%

Anti‑inflammatory effects of Simvastatin in patients with acute intracerebral hemorrhage in an intensive care unit

et al. 2017

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“…Cerebral hemorrhage is the most common human type of cerebrovascular disease (accounting for 20-30% of cases) and the least treatable subtype of hemorrhagic stroke, with a mortality rate ~30-40% (1). The most common clinical manifestations are cerebral arteriosclerosis, hypertension and intracranial vascular malformations (2). Cerebral hemorrhage is often provoked by exertion and emotion and the majority of patients present sudden onset during activity.…”

Section: Introductionmentioning

confidence: 99%

Cerebral hemorrhage therapy by targeting VEGF and HGF in a preclinical trial in rats

Rui-qi

et al. 2017

Molecular Medicine Reports

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Cerebral hemorrhage is the most common type of human cerebrovascular disease and frequently causes paralysis, vegetative state and mortality. The modulatory actions of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) are vital in the human nervous system. The present study investigated the association between cerebral hemorrhage and the expression of VEGF and HGF in a rat model of cerebral hemorrhage. The therapeutic potential of cerebral hemorrhage was also evaluated using targeted drugs for VEGF and HGF in the cerebral hemorrhage rat model. Behavioral and preclinical changes and the survival rates of rats were assessed after treatment with VEGF receptor (VEGFR) and HGF receptor (HGFR). The results of Tarlov scores demonstrated that movement of limbs and coordination when walking were significantly improved in moderate and severe hemorrhage lesions in the VEGFR plus HGFR‑treated group and mainly alleviated in primary hemorrhage lesions compared with rats in the single VEGFR or HGFR‑treated groups and the control group (**P<0.01). Decreasing expression levels of VEGF and HGF were observed in the neural tissue of animals treated with VEGFR plus HGFR compared with the control group (**P<0.01). These preclinical observations indicated that VEGF and HGF serve a function in the pathological injury and repair of cerebral tissue in rats with cerebral hemorrhages. The therapeutic benefits of VEGFR plus HGFR suggested that VEGFR plus HGFR may be candidate drugs for cerebral hemorrhage, and thus offer a promising treatment for clinicians and doctors.

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Pathologie infectieuse

Dietemann¹,

Eid²,

Koob³

et al. 2018

Neuro-Imagerie Diagnostique

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A Delayed Cerebral Vasospasm with Infarction Is Secondary to <i>Listeria monocytogenes</i> Meningitis: MRI and MRA Are Diagnostically Useful

Cited by 4 publications

References 15 publications

Anti‑inflammatory effects of Simvastatin in patients with acute intracerebral hemorrhage in an intensive care unit

Anti‑inflammatory effects of Simvastatin in patients with acute intracerebral hemorrhage in an intensive care unit

Cerebral hemorrhage therapy by targeting VEGF and HGF in a preclinical trial in rats

Pathologie infectieuse

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