A Demographic and Biochemical Analytic of Cases of G6PD Deficiency: A Cross-Sectional Study from the Middle East

Abstract

BACKGROUND
 G6PD deficiency is an inherited an X-linked recessive condition leading to insufficient levels of glucose-6-phosphate dehydrogenase, thus causing hemolytic anaemia under certain conditions. 
 METHODS
 Our study is explorative for cases admitted to Jordan University Hospital. The studied parameters include demographics, clinical manifestations, biochemical markers including Hb level, WBC count, liver enzymes, and blood grouping. 
 RESULTS 
 Most of the patients were admitted to the emergency unit (53.13%). Individuals who were Rh-positive represented 57.81%, while patients of AB blood group accounted for 75%. The mean values were 4.81 years (age), 29.06 hours (time-to-hospital admission), 38.10 degree Celsius (temperature), 6.11 gm/dl (Hb), 13242.19 (WBC count), 343.20 U/L (S. ALP), and 50.98 IU/L (S. ALT). There was no significant difference between males and females or between favism-induced versus drug-induced hemolytic episodes. AB and Rh positive blood groups are of protective effect in relation to liver enzymes. Patients who were admitted to the hospital within 24 hours from having clinical manifestations had a better prognosis. 
 CONCLUSION
 This study is the first inferential research on G6PD deficiency from the Middle East to explore cases from one of the largest healthcare centres in Jordan. The role of blood grouping should be investigated prospectively.

The enzymopathy of G6PD deficiency in Jordan: a demographic and biochemical analysis

“…10,11 The incorporation of concepts of machine learning and real-time analytics will provide an enormous impact of the level-of-evidence of studies as well as offer a preemptive warning system for mass casualties due to hemolytic anaemias clustered in a specific region of the world. [12][13][14][15] The benefits for public health and G6PD deficiency is not only the most common red blood cell enzymopathy but also represents the most common of all clinically significant enzyme defects of human biology as a whole [16][17][18] G6PD deficiency constitutes a significant public health problem in the Middle East. 19,20 The highest incidence of G6PD deficiency has been described in Sardinia.…”