A demographic and clinical panorama of a sixteen-year cohort of soft tissue sarcoma patients in Brazil

Abstract

Little is known about soft tissue sarcomas (STS) in Brazil, once the federal statistics regarding estimates on incidence and mortality of the most common cancers that affect the Brazilian population currently do not include STS. This study aims to perform a broad evaluation and description of the epidemiological profile, access to treatment and main clinical outcomes of the Brazilian STS patient. A population-based cohort study of 66,825 patients who underwent procedures related to STS treatment registered in the Brazilian public health system (Sistema Único de Saúde, SUS) databases. Median age was 57 years, 30% of them older than 65 years and 50.7% of the cohort was female. The majority, 50,383 patients (75.4%), was diagnosed between 2008 and 2015. Most prevalent anatomic sites were upper and lower limbs (12.6%) and the registry of sarcomas without a specific location comprehended 29.7% of the cohort. The majority of patients resided in the Northeast (40.2% of the patients). Surgery was the first treatment modality in 77.7% of the cases. For survival analysis, only patients with stage and histological grade information were included. The 1-, 5- and 10-year survival rate of the patients was, respectively, 75.4% (95% CI = 74.1–76.7%), 43.4% (95% CI = 41.5–45.5%) and 18.6% (95% CI = 14.8–23.3%).

Soft-Tissue Sarcomas in Adults in Ecuador in the Period 2010–2020

“…The data reported in several studies do not show a gender distribution; however, our results show an almost uniform distribution between genders, with a slight majority of patients being male (50.61%) and living in the highlands, results that are similar to those published by Bozzo et al in Canada [ 11 ] in a five-year cohort study. However, these data are in contrast with those reported in Brazil in a sixteen-year cohort study where soft-tissue sarcomas were reported to be slightly higher in females [ 12 ]. The results of this study in this sense resemble those of a ten-year retrospective cohort study in Germany that reported an even distribution between genders [ 13 ].…”

Venous Reconstruction in Extremity Soft Tissue Sarcoma Is Not Essential

“…7 However, limb amputation severely limits functional ability. Extremity STS affects people with a median age in the 50s, 8 who are usually socioeconomically active in society, as in our patients. Chemotherapy for STS has increased the 5-year survival rates with localized tumors up to 60%.…”

Challenges and opportunities for sarcoma care and research in Latin America: a position paper from the LACOG sarcoma group

“…The elegant analysis by Figueiredo and colleagues highlights the paucity and poor quality of available data in Brazil. 21 In this report, sarcomas with an unspecified location or identified as invasive but lacking a precise location constituted 29.7% of the study group. Moreover, tumour grade and clinical staging sub-registrations were noted, with grade X (undefined) and indeterminate clinical stage being the most frequently recorded for these variables, at 91.3% and 79.5% respectively.…”

“…Examples include research by Dr DelaGarza-Montano examining the epidemiology of musculoskeletal tumours at Mexico City's National Rehabilitation Institute, by Dr Lopes David evaluating sarcoma burden and pathways in hospital-based registries in Brazil, by Dr Chávez describing patients with soft tissue sarcoma treated at the National Institute of Neoplastic Diseases of Peru, and by Dr Figueiredo evaluating public databases in Brazil, among others. 8 , 19 , 20 , 21 The single publication addressing the incidence of soft tissue sarcomas in the region based on a Population-based Cancer Registry is from the City of São Paulo, Brazil, in which it was estimated to be 3.36/100.000 habitants. 21 …”

“… 8 , 19 , 20 , 21 The single publication addressing the incidence of soft tissue sarcomas in the region based on a Population-based Cancer Registry is from the City of São Paulo, Brazil, in which it was estimated to be 3.36/100.000 habitants. 21 …”