The electron-impact single ionization of low-charged Ti ions was studied both experimentally and theoretically. Absolute cross sections for Ti q+ ions in charge states q = 1 to 6 except 3 were measured using a crossed-beams technique as well as calculated with the configuration-average distorted-wave method, including both direct ionization and excitationautoionization contributions. For charge states q = 4, 5 and 6, the measurements are in good agreement with the calculations considering that large components of the incident ion beam were in metastable configurations. The cross sections for single ionization of Ti 5+ and Ti 6+ were determined in part with a high-resolution energy-scan method. Besides contributions of excitation-autoionization mechanisms, a remarkable number of structures arising from resonantexcitation double-autoionization (REDA) processes could be observed.