A Depression in Left Ventricular Diastolic Filling following Prolonged Strenuous Exercise is Associated with Changes in Left Atrial Mechanics

Oxborough, David; Whyte, Greg; Wilson, Mathew; O’Hanlon, Rory; Birch, Karen M.; Shave, Rob; Smith, Gillian; Godfrey, Richard; Prasad, Sanjay K.; George, Keith

doi:10.1016/j.echo.2010.06.002

Cited by 53 publications

(58 citation statements)

References 42 publications

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“…Chan Dewar and colleagues 29 demonstrated an increase in time to peak myocardial velocities from both the LV and RV after an 89-km ultramarathon, whereas other work demonstrated increased time to peak LV twist and untwist after prolonged exercise. 9,13 From these data, it is difficult to speculate whether any mechanism underpins this delay; however, both an intrinsic delay in contractility and response to an elevated RV afterload possibly could generate these findings. The consistent findings across the cohort (with some more-extreme cases) of changes to RV structure and function further support the theory that the relative increase in stroke work during endurance exercise is greater in the RV than in the LV partly because of a proposed smaller rate of decrease in pulmonary resistance than in the systemic circulation.…”

Section: Oxborough Et Al Right Ventricular Function After An Ultramarmentioning

confidence: 88%

“…LA data from the lateral wall was obtained, providing peak and temporal indices of deformation during ventricular systole, ventricular diastole, and atrial contraction as previously described. 9 Data collected by our group before the present study have demonstrated acceptable intraobserver variation in all peak LV and LA and SR data. 9 A further 20 subjects with 2 separate acquisitions were analyzed for RV intraobserver variation, giving …”

Section: Two-dimensional Myocardial Speckle Trackingmentioning

confidence: 99%

“…9 Data collected by our group before the present study have demonstrated acceptable intraobserver variation in all peak LV and LA and SR data. 9 A further 20 subjects with 2 separate acquisitions were analyzed for RV intraobserver variation, giving …”

Section: Two-dimensional Myocardial Speckle Trackingmentioning

confidence: 99%

“…The changes in RV and LV function after prolonged exercise are likely transient, 9 representing a "cardiac fatigue" process from which well-trained athletes recover. Despite these important points, both the short-term and the long-term effects of training and competing in ultraendurance athletics has received little clinical attention.…”

Section: Oxborough Et Al Right Ventricular Function After An Ultramarmentioning

confidence: 99%

“…In a recent study by our group, a transient depression in both LV and left atrial (LA) function was reported in athletes after running a marathon, with a link postulated between a postrace reduction in LA deformation and RV function. 9 This study…”

mentioning

confidence: 99%

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Dilatation and Dysfunction of the Right Ventricle Immediately After Ultraendurance Exercise

Oxborough

Shave

Warburton

et al. 2011

Circ: Cardiovascular Imaging

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141

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Background-Running an ultramarathon has been shown to have a transient negative effect on right ventricular (RV) and left ventricular (LV) function. Additionally, recent findings suggested that ultraendurance athletes may be more at risk of developing a RV cardiomyopathy. The standard echocardiographic assessment of RV function is problematic; however, the introduction of ultrasonic speckle tracking technology has the potential to yield a comprehensive evaluation of RV longitudinal function, providing new insights into this phenomenon. Thus, the primary aim of this exploratory study was to evaluate comprehensively RV structure and function after a 161-km ultramarathon and establish whether changes in the RV are associated with alterations in LV function. Methods and Results-Myocardial

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Section: Oxborough Et Al Right Ventricular Function After An Ultramarmentioning

confidence: 88%

Section: Two-dimensional Myocardial Speckle Trackingmentioning

confidence: 99%

Section: Two-dimensional Myocardial Speckle Trackingmentioning

confidence: 99%

Section: Oxborough Et Al Right Ventricular Function After An Ultramarmentioning

confidence: 99%

mentioning

confidence: 99%

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Dilatation and Dysfunction of the Right Ventricle Immediately After Ultraendurance Exercise

Oxborough

Shave

Warburton

et al. 2011

Circ: Cardiovascular Imaging

Self Cite

141

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Cardiac and renal biomarkers in recreational runners following a 21 km treadmill run

Yeo

Ling

Lam

et al. 2020

Clinical Cardiology

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Background: Highly trained athletes running 42 km or more demonstrate elevated cardiac biomarkers, ventricular dysfunction, and decreased glomerular filtration rate (GFR). Whether similar changes occur in the much larger population of recreational runners following half-marathon distance running is unclear. Hypothesis: Recreational runners exhibit changes in myocardial and renal biomarkers, including ventricular strain, after a half-marathon treadmill run. Methods: 10 recreational subjects (mean age 36.5 ± 6.5 years) ran 21 km on a treadmill (mean completion time 121.6 ± 16.1 minutes). Serum high-sensitivity troponin T (hsTnT), amino-terminal pro-brain natriuretic peptide (NT-proBNP), creatinine, and neutrophil gelatinase-associated lipocalin (NGAL) were measured prior to, 1 hour post-, and 24 hours post-exercise. Pre-and post-exercise echocardiograms were performed. Results: All biomarkers increased 1 hour post-exercise: hsTnT by 8.5 ± 8.5 pg/ml (P < .05), NT-ProBNP by 26.2 ± 22.8 pg/ml (P < .05) and NGAL by 29.5 ± 37.7 ng/ml (P=NS). By 24 hours post-run, these biomarkers declined toward baseline levels. Right ventricle (RV) free wall and left ventricle global longitudinal strain decreased by 5.5% and 1.8%, respectively (P < .001). Changes in NGAL correlated well with changes in serum creatinine (R = 0.79, P < .01

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Medical Evaluation of Athletes: Echocardiography

D’Ascenzi

Oxborough

2020

Textbook of Sports and Exercise Cardiology

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A Depression in Left Ventricular Diastolic Filling following Prolonged Strenuous Exercise is Associated with Changes in Left Atrial Mechanics

Cited by 53 publications

References 42 publications

Dilatation and Dysfunction of the Right Ventricle Immediately After Ultraendurance Exercise

Dilatation and Dysfunction of the Right Ventricle Immediately After Ultraendurance Exercise

Cardiac and renal biomarkers in recreational runners following a 21 km treadmill run

Medical Evaluation of Athletes: Echocardiography

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