A description of the antibiotic bacitracin: Its topical use in the treatment of Vincent's infection

Kozol, Solomon M.; Shuster, Herbert V.

doi:10.1016/0030-4220(52)90105-9

Cited by 4 publications

(1 citation statement)

References 29 publications

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“…Several investigators have studied the effects of locally applied antibiotics on gingivitis and some have commented on their influence on the gingival plaque flora (Mac-Gregor and Long 1945, Webster and Erey 1947, Goldman and Bloom 1950, Rosenthal and Winter 1950, Kozol and Shuster 1952. Shpuntoff and Shpuntoff 1954, Grupe and Wilder 1956, Hillmann 1956, Jensen 1956, Mitchell and Holmes 1965.…”

Section: Discussionmentioning

confidence: 99%

Experimental gingivitis in man

Löe¹,

Theilade²,

Sb³

et al. 1967

J of Periodontal Research

612

606

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During a 5 day period without oral hygiene, 4 groups each consisting of 3 subjects with healthy gingivae, rinsed their mouths with solutions of tetracycline, vancomycin, polymyxin B or distilled water. Gingival plaque accumulated rapidly in the group rinsing with water, while tetracycline, and to a lesser degree vancomycin and polymyxin B inhibited plaque formation. Clinical gingivitis was not observed in any of the participants, but gingival exudate and leukocyte emigration were noted and seen to increase during the experimental period, especially in the water group. Rinsing with antibiotics inhibited these signs of subclinical inflammation to varying degrees. The bacterial composition of the gingival plaque changed in the water group during the experimental period towards a higher percentage of gram‐negative bacteria, following the pattern observed in previous investigations. Tetracycline markedly reduced the numbers of gingival plaque organisms, while polymyxin B favored a proliferation of gram‐positive cocci and short rods and depressed gram‐negative bacteria. Rinsing with vancomycin resulted in a pronounced shift towards an almost pure gram‐negative plaque flora. It is concluded that local administration of antibiotics with a limited spectrum may be useful for the study of the pathogenicity of the different components of the gingival microbial flora.

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Section: Discussionmentioning

confidence: 99%

Experimental gingivitis in man

Löe¹,

Theilade²,

Sb³

et al. 1967

J of Periodontal Research

612

606

View full text Add to dashboard Cite

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A Consideration of Topical Antibiotic Therapy in Dentistry

Knighton

1958

Dental Clinics of North America

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Antimicrobial Control of Bacterial Plaque and Calculus and the Effects of these Agents on Oral Flora

et al. 1969

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An in vivo clinical program investigated the relationship among oral microorganisms, bacterial plaque, and calculus formation. Benzethonium chloride, cetylpyridinium chloride, and Vancomycin provided a moderate reduction in bacterial plaque accumulation (30 to 35%). Hexachlorophene was relatively ineffective. One antibiotic, CC 10232, consistently furnished substantial reductions in plaque formation (70 to 77%) and calculus formation (75%). Only Vancomycin significantly reduced the gram-positive population. None of the antimicrobial agents caused changes in the staphylococcal or yeast populations.

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A description of the antibiotic bacitracin: Its topical use in the treatment of Vincent's infection

Cited by 4 publications

References 29 publications

Experimental gingivitis in man

Experimental gingivitis in man

A Consideration of Topical Antibiotic Therapy in Dentistry

Antimicrobial Control of Bacterial Plaque and Calculus and the Effects of these Agents on Oral Flora

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