A descriptive hospital based study of rotavirus diarrhoea in children aged 6 months to 3 years

Singh, Gursharan; Singh, Gagan D.; Arora, Sunita; Singh, Gurmeet; Aggarwal, Aruna

doi:10.4038/sljch.v43i4.7766

Cited by 3 publications

(8 citation statements)

References 12 publications

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“…Drinking water from an unsafe source is one of the most important and common causes of rotavirus infections in developing countries [ 9 - 10 ]. The waterborne acute gastroenteritis due to Group B rotavirus is mainly found amongst children and adults of India, Bangladesh, Myanmar, and China [ 1 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Anthropometry was done to find out the grade of malnutrition. Children were assessed for dehydration signs and classified into severe, some, or no dehydration [ 1 , 4 ].…”

Section: Methodsmentioning

confidence: 99%

“…Rotavirus is the most common cause of acute gastroenteritis (AGE) and severe dehydration among children of less than five years of age in India [ 1 , 2 ]. About 11.37 million illnesses, 3.27 million outpatient visits, and 872,000 inpatient admissions occur each year due to rotavirus infection.…”

Section: Introductionmentioning

confidence: 99%

“…The rotavirus belongs to the Reoviridae family. Rotavirus is a non-enveloped double-stranded RNA genome, consisting of 11 gene segments within a multilayered protein capsid [ 1 , 3 ]. Out of 11 gene segments, six are structural proteins (VP1, VP2, VP3, VP4, VP6, and VP7) organized in a concentric layer around the genome, and the rest of the gene segments are non-structural proteins (NSP).…”

Section: Introductionmentioning

confidence: 99%

“…Several health organizations across the globe have promoted rotavirus vaccination. Guidelines and recommendations are provided by the World Health Organization (WHO), the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition, and by the European Society for Paediatric Infectious Diseases [ 1 , 4 ]. As data is unavailable for the rotavirus positivity from western Rajasthan, the current study was planned to determine the burden of rotavirus in acute watery diarrhea and its circulating genotypes in hospitalized children of less than five years for acute gastroenteritis.…”

Section: Introductionmentioning

confidence: 99%

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The Burden of Rotavirus Gastroenteritis in Children: A Hospital-Based Prospective Study in Western Rajasthan

Meel

Katewa

Singh

et al. 2020

Cureus

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Objective Rotaviruses are the prime cause of gastroenteritis amongst infants and young children worldwide. In India, the mortality and economic impact caused by rotavirus are high. The objective of this is to understand the burden of rotavirus in acute watery diarrhea and its circulating genotypes in hospitalized children less than five years of age for acute gastroenteritis in western Rajasthan. Methodology This is a hospital-based prospective study conducted in the pediatrics department of Dr. Sampurnanand (S.N.) Medical College of Jodhpur in India for one year during 2018. The study included 399 children less than five years old, presenting with acute gastroenteritis who needed to be admitted for at least six hours. We enrolled subjects after obtaining informed consent from the guardian. Stool samples of 5 gm or ml were collected in a sterile container and stored at minus 20 degrees centigrade while transporting to Christian Medical College (CMC) virology lab in Vellore, India. The stool samples were subjected to Enzyme-Linked Immunosorbent Assay (ELISA) testing, followed by genotype determination. We investigated data through statistical analysis from all collected data. Results A total of 399 patients fulfilled the enrollment criteria; out of them, 92 (23.05%) were positive for rotavirus, and maximum cases were seen in the age group of six months to two years (78.26%). Rotavirus positivity was more in males (64.13%) than females (35.86%). The rotavirus infection was seen throughout the year, with a peak in cases from November to February (73.91%). G3P8 (55.43%) was the most common strain causing rotavirus diarrhea, followed by G1P8 (9.72%) and G3+G12P8 (8.69%). Based on the Vesikari clinical severity score, 70.65% of patients had severe diarrhea. Conclusion This prospective study highlights the healthcare and economic burden of rotavirus, especially in children of less than five years. The incidence of rotavirus is observed in winter months, and its prevalence in all cases of acute diarrhea in our study is 23.05%. G3P8 was the most common genotype causing rotavirus diarrhea in our region in both non-vaccinated and vaccinated children, followed by G1P8 and G3+G12P8, respectively.

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Section: Discussionmentioning

confidence: 99%

“…Anthropometry was done to find out the grade of malnutrition. Children were assessed for dehydration signs and classified into severe, some, or no dehydration [ 1 , 4 ].…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Burden of Rotavirus Gastroenteritis in Children: A Hospital-Based Prospective Study in Western Rajasthan

Meel

Katewa

Singh

et al. 2020

Cureus

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Clinicoepidemiological Profile and Genetic Characterization of Circulating Rotavirus Strain among Children < 5 Years Hospitalized for Acute Gastroenteritis in Western Rajasthan, India

et al. 2021

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Prevalence of rotavirus infection and its association with socio-demographic characteristics among under-five children admitted with acute diarrhoea in a tertiary care hospital of Bangladesh

et al. 2021

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Background: Rotavirus has been recognized as the most common cause of acute watery diarrhoea among under-five children worldwide. It is considered as a major cause of childhood morbidity and mortality particularly in developing countries like Bangladesh. Considering the high morbidity and significant mortality, this study was designed to evaluate the prevalence of rotaviral diarrhoea among children less than five years in Sylhet region of Bangladesh. Methods: This cross-sectional study was conducted in the Department of Microbiology, Sylhet MAG Osmani Medical College from 1st January to 31st December, 2018. Total 184 under-five children admitted in paediatrics department of the same institute with acute watery diarrhoea were enrolled in this study by convenient sampling. Stool samples were obtained and assayed for rotavirus antigen by sandwich type enzyme linked immunosorbent assay (ELISA). Results: Rotaviral antigen was found positive in 86 cases and disease prevalence was 46.74%. The rotavirus infection was found highest in age group of 7 to 12 months (50.56%) and in male (59.30%) children. Prevalence of infection was associated with age (p= 0.004), socio-economic condition (p=0.001) and exclusive breastfeeding of children (p=0.01). Conclusion: Rotavirus was a significant cause of acute watery diarrhoea and mainly affected children below 12 months age. BIRDEM Med J 2021; 11(3): 186-190

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A descriptive hospital based study of rotavirus diarrhoea in children aged 6 months to 3 years

Abstract: Objective: To study the prevalence, demographic characteristics, clinical characteristics, laboratory parameters and therapy of rotavirus diarrhoea in children aged 6 months to 3 years in a hospital setting

Cited by 3 publications

References 12 publications

The Burden of Rotavirus Gastroenteritis in Children: A Hospital-Based Prospective Study in Western Rajasthan

The Burden of Rotavirus Gastroenteritis in Children: A Hospital-Based Prospective Study in Western Rajasthan

Clinicoepidemiological Profile and Genetic Characterization of Circulating Rotavirus Strain among Children < 5 Years Hospitalized for Acute Gastroenteritis in Western Rajasthan, India

Prevalence of rotavirus infection and its association with socio-demographic characteristics among under-five children admitted with acute diarrhoea in a tertiary care hospital of Bangladesh

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