A Design-of-Experiments approach to developing thermoresponsive gelators from complex polymer mixtures

Abstract

This study investigated the effects of additives on the properties of poloxamer (P) 407 thermogels, employing a design-of-experiments (DoE) approach. P407 is a thermoresponsive triblock copolymer that exhibits a solution...

Liquid–liquid phase separation in aqueous solutions of poly(ethylene glycol) methacrylate homopolymers

“…PEG homopolymers have been previously studied as polymeric additives in Pluronic® solutions, 41,45–48 with the disruption of gelation by the addition of PEG being consistent with what has been previously reported in the literature 45,46 . More specifically, it has been observed that the addition of PEG with MM ≥2000 g mol −1 increases the polydispersity in micelle size, which is attributed to the formation of micelle clustering.…”

Experimentally designed chemometric models for the assay of toxic adulterants in turmeric powder

“…The DoE technique has been used extensively in several fields, such as chemistry, 24–29 agriculture, 30,31 engineering, 32,33 industry 34,35 (in particular food industry 36–38 ), and even in non-scientific aspects, such as predicting sports results, 39 especially soccer and basketball. DoE can be used in other disciplines, such as energy 40–44 and sensors optimization.…”

Homopolymer and ABC Triblock Copolymer Mixtures for Thermoresponsive Gel Formulations

“…Several studies have investigated the effect of additives on the thermoresponsive properties of the polymers, with major focus on Pluronic ® F127 (poloxamer 407) [26,27]. Pluronic ® polymers are ABA triblock copolymers, where A and B consist of ethylene glycol (EG) and propylene glycol (PG), respectively [12].…”

“…Pluronic ® F127 has an EG content of approximately 70% and a total MM of approximately 12600 g mol −1 , and it has gained much attention due to its interesting thermogelling properties and commercial availability [12]. Polymeric additives in solutions of Pluronic ® F127, such as alginate [28][29][30], poly(ethylene glycol) (PEG) [27,[31][32][33][34][35], poly(acrylic acid) (PAA) [27,36], and carbopols, i.e., crosslinked PAA [37], poly(vinyl alcohol) [27,38], and hyaluronic acid [39,40], have been investigated. Poloxamers as polymeric additives in solutions of Pluronic ® F127 have also been studied [19,[41][42][43][44][45][46][47][48].…”

“…Poloxamers as polymeric additives in solutions of Pluronic ® F127 have also been studied [19,[41][42][43][44][45][46][47][48]. For example, mixtures of Pluronic ® F127 and Pluronic ® F68, EG content 80% and total MM 8350 g mol −1 [12], were tested for suitability in drug delivery [19,27,44,[46][47][48][49][50]. In two of these studies, increasing the content in Pluronic ® F68 while keeping the content in Pluronic ® F127 constant lowered the gelation time at body temperature and drug diffusion kinetics were improved when this formulation was applied in drug delivery [46,47].…”