A design process for a 3D printed patient-specific applicator for HDR brachytherapy of the orbit

Subashi, Ergys; Jacobs, Corbin; Hood, Rodney; Kirsch, David G.; Craciunescu, Oana

doi:10.1186/s41205-020-00068-3

Cited by 10 publications

(11 citation statements)

References 17 publications

(20 reference statements)

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“…Furthermore, 3D printed models are now entering clinical use. In the field of oculoplastic surgery, for example, they are being used for orbital fracture reduction and orbital brachytherapy and to create orbital prostheses [ 9 , 18 , 19 ]. Elaborate personalized 3D printed models can be reproduced and processed freely, as with the different decompression models created in our study.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the decompressive effect of different surgical procedures for dysthyroid optic neuropathy using 3D printed models

Nishimura

Takahashi

et al. 2022

Graefes Arch Clin Exp Ophthalmol

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Purpose To compare the decompressive effect around the optic nerve canal among 3 different decompression procedures (medial, balanced, and inferomedial) using 3D printed models. Methods In this experimental study, based on data obtained from 9 patients (18 sides) with dysthyroid optic neuropathy, a preoperative control model and 3 plaster decompression models were created using a 3D printer (total, 72 sides of 36 models). A pressure sensor was placed at the optic foramen, and the orbital space was filled with silicone. The surface of the silicone was pushed down directly, and changes in pressure were recorded at 2-mm increments of pushing. Results At 10 mm of pushing, there was significantly lower pressure in the medial (19,782.2 ± 4319.9 Pa, P = 0.001), balanced (19,448.3 ± 3767.4 Pa, P = 0.003), and inferomedial (15,855.8 ± 4000.7 Pa, P < 0.001) decompression models than in the control model (25,217.8 ± 6087.5 Pa). Overall, the statistical results for each 2-mm push were similar among the models up to 10 mm of pushing (P < 0.050). At each push, inferomedial decompression caused the greatest reduction in pressure (P < 0.050), whereas there was no significant difference in pressure between the medial and balanced decompression models (P > 0.050). Conclusion All 3 commonly performed decompression procedures significantly reduced retrobulbar pressure. Because inferomedial decompression models obtained the greatest reduction in pressure on the optic nerve canal, inferomedial decompression should be considered the most reliable procedure for rescuing vision in dysthyroid optic neuropathy.

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Section: Discussionmentioning

confidence: 99%

Comparison of the decompressive effect of different surgical procedures for dysthyroid optic neuropathy using 3D printed models

Nishimura

Takahashi

et al. 2022

Graefes Arch Clin Exp Ophthalmol

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“…3D-printed parts have also begun to be incorporated into the delivery of radiation therapy near the eye. Plaque brachytherapy applicators for ocular radiation have been printed [ 129 , 130 ]. 3D printing of an external applicator for delivery of radiation to an orbital fibrous solitary tumor has been demonstrated [ 131 ].…”

Section: Methodsmentioning

confidence: 99%

3D Printing in Eye Care

2021

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Three-dimensional printing enables precise modeling of anatomical structures and has been employed in a broad range of applications across medicine. Its earliest use in eye care included orbital models for training and surgical planning, which have subsequently enabled the design of custom-fit prostheses in oculoplastic surgery. It has evolved to include the production of surgical instruments, diagnostic tools, spectacles, and devices for delivery of drug and radiation therapy. During the COVID-19 pandemic, increased demand for personal protective equipment and supply chain shortages inspired many institutions to 3D-print their own eye protection. Cataract surgery, the most common procedure performed worldwide, may someday make use of custom-printed intraocular lenses. Perhaps its most alluring potential resides in the possibility of printing tissues at a cellular level to address unmet needs in the world of corneal and retinal diseases. Early models toward this end have shown promise for engineering tissues which, while not quite ready for transplantation, can serve as a useful model for in vitro disease and therapeutic research. As more institutions incorporate in-house or outsourced 3D printing for research models and clinical care, ethical and regulatory concerns will become a greater consideration. This report highlights the uses of 3D printing in eye care by subspecialty and clinical modality, with an aim to provide a useful entry point for anyone seeking to engage with the technology in their area of interest.

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“…Agilus30 ® and TangoPlus ® family polymers were mixed at a ratio of 20/80 for the primary applicator, whereas for the sheath, the ratio was set at 20/80. The applicator was printed on a J750 PolyJet 3D printer [ 51 ].…”

Section: Design and Fabrication Of Customized Skin Applicators Using ...mentioning

confidence: 99%

“… Graphical representation of the designed and fabricated customized skin applicators. A ) Model view of an orbit applicator [ 51 ]; B, C ) View of the applicator at different angles [ 51 ]; D ) 3D-printed applicator with the patient face printed [ 20 ]. All images from [ 20 ] were obtained with the permission of Elsevier …”

Section: Design and Fabrication Of Customized Skin Applicators Using ...mentioning

confidence: 99%

Brachytherapy and 3D printing for skin cancer: A review paper

Poltorak,

Banatkiewicz,

Poltorak

et al. 2024

jcb

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Brachytherapy is a type of radiation therapy, in which a radiation source is placed directly or close to a tumor. It is commonly used to treat skin cancer, and enables precise irradiation treatment of affected area (planning target volume – PTV) while minimizing exposure dose to surrounding healthy tissue (organs at risk – OARs). Recently, the use of 3D printing has begun revolutionizing brachytherapy, as it allows manufacturing of custom-designed applicators for unique shape of skin topography, tumor, and surrounding tissues. Outcome of the combination of 3D printing and brachytherapy has several advantages over traditional treatment planning methods. Some of the advantages are intuitive, whereas others can be concluded from a literature overview as follows: 1) Possibility of developing patient-specific applicators that precisely match the shape of tumor area; 2) Reduction of the time required for applicator production, especially when custom-made devices are needed; 3) Reduction of manufacturing costs; 4) Treatment procedures improvement; 5) Improvement of safety measures accelerated by the development of smart materials (e.g., polymer filaments with admixture of heavy elements); 6) Possibility of nearly instant adjustment into tumor treatment (applicators can be changed as the tumor is changing its shape); and 7) Applicators designed to securely fit to treatment area to hold radioactive source always in the same place for each fraction. Consequently, tumor-provided dose is accurate and leads to effective treatment. In this review paper, we investigated the current state-of-the-art of the application of 3D printing in brachytherapy. A number of existing reports were chosen and reviewed in terms of printing technology, materials used, treatment effectiveness, and fabrication protocols. Furthermore, the development of future directions that should be considered by collaborative teams bridging different fields of science, such as medicine, physics, chemistry, and material science were summarized. With the indicated topics, we hope to stimulate the innovative progress of 3D printing technology in brachytherapy.

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A design process for a 3D printed patient-specific applicator for HDR brachytherapy of the orbit

Cited by 10 publications

References 17 publications

Comparison of the decompressive effect of different surgical procedures for dysthyroid optic neuropathy using 3D printed models

Comparison of the decompressive effect of different surgical procedures for dysthyroid optic neuropathy using 3D printed models

3D Printing in Eye Care

Brachytherapy and 3D printing for skin cancer: A review paper

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