A detailed experimental and Monte Carlo analysis of gold nanoparticle dose enhancement using 6 MV and 18 MV external beam energies in a macroscopic scale

Gray, Tara; Bassiri, Nema; David, Shaquan; Patel, Devanshi Yogeshkumar; Stathakis, Sotirios; Kirby, Neil; Mayer, Kathryn M.

doi:10.1016/j.apradiso.2021.109638

Cited by 12 publications

(7 citation statements)

References 48 publications

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“…To the best of our knowledge, comparable data were available in the literature only for lower energy photons after excitation of gold M-shells [58] and for irradiations with protons [52], but in both cases only on a relative scale. Experimental benchmarks of numerical methods for determining dose enhancement by high-Z materials have been performed by Alawi et al [22], Mirza et al [23] and Gray et al [24]. However, the respective experiments do not allow conclusions to be drawn about the energy spectra of emitted electrons as they determined the integral dosimetric effect.…”

Section: Discussionmentioning

confidence: 99%

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Experimental benchmark data for Monte Carlo simulated radiation effects of gold nanoparticles. Part I: Experiment and raw data analysis

et al. 2023

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Electron emission spectra of gold nanoparticles (AuNPs) after photon interaction were measured over the energy range between 50 eV and 9500 eV to provide reference data for Monte Carlo radiation-transport simulations. Experiments were performed with the HAXPES spectrometer at the PETRA III high-brilliance beamline P22 at DESY (Hamburg, Germany) for photon energies below and above each of the gold L-edges, that is, at 11.9 keV, 12.0 keV, 13.7 keV, 13.8 keV, 14.3 keV, and 14.4 keV. The study focused on a sample with gold nanoparticles with an average diameter of 11.0 nm on a thin carbon foil. Additional measurements were performed on a sample with 5.3 nm gold nanoparticles and on reference samples of gold and carbon foils. Further measurements were made to calibrate the photon flux monitor, to characterize the transmission function of the electron spectrometer, and to determine the size of the photon beam. This allowed the determination of the absolute values of the spectral particle radiance of secondary electrons per incident photon flux. The paper presents the experimental and raw data analysis procedures, reviews the data obtained for the nanoparticle samples, and discusses their limitations.

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Section: Discussionmentioning

confidence: 99%

“…Benchmarking MC simulations of the dosimetric effects of AuNPs with experimental data is challenging. Previous experimental studies were moreover limited to determining the macroscopic average dose increase [22][23][24]. In addition, the measurement of locally enhanced dose in the vicinity of AuNPs is not yet possible for two reasons.…”

Section: Introductionmentioning

confidence: 99%

Experimental benchmark data for Monte Carlo simulated radiation effects of gold nanoparticles. Part I: Experiment and raw data analysis

et al. 2023

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“…This technique uses a mathematical algorithm to simulate the transport of radiation particles in a given medium and is particularly useful in predicting the dose distribution in complex biological systems [ 14 ]. In nanoparticle-enhanced radiotherapy, Monte Carlo simulation can be used to predict the dose enhancement ratio, which is the ratio of the dose delivered to a tissue with nanoparticles to the dose delivered without nanoparticles [ 15 ]. This information can help optimize the nanoparticle concentration and photon beam energy used in radiotherapy to achieve the greatest therapeutic benefit while minimizing damage to healthy tissues [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Depth Dose Enhancement in Orthovoltage Nanoparticle-Enhanced Radiotherapy: A Monte Carlo Phantom Study

Chow,

Jubran

2023

Micromachines

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Background: This study was to examine the depth dose enhancement in orthovoltage nanoparticle-enhanced radiotherapy for skin treatment by investigating the impact of various photon beam energies, nanoparticle materials, and nanoparticle concentrations. Methods: A water phantom was utilized, and different nanoparticle materials (gold, platinum, iodine, silver, iron oxide) were added to determine the depth doses through Monte Carlo simulation. The clinical 105 kVp and 220 kVp photon beams were used to compute the depth doses of the phantom at different nanoparticle concentrations (ranging from 3 mg/mL to 40 mg/mL). The dose enhancement ratio (DER), which represents the ratio of the dose with nanoparticles to the dose without nanoparticles at the same depth in the phantom, was calculated to determine the dose enhancement. Results: The study found that gold nanoparticles outperformed the other nanoparticle materials, with a maximum DER value of 3.77 at a concentration of 40 mg/mL. Iron oxide nanoparticles exhibited the lowest DER value, equal to 1, when compared to other nanoparticles. Additionally, the DER value increased with higher nanoparticle concentrations and lower photon beam energy. Conclusions: It is concluded in this study that gold nanoparticles are the most effective in enhancing the depth dose in orthovoltage nanoparticle-enhanced skin therapy. Furthermore, the results suggest that increasing nanoparticle concentration and decreasing photon beam energy lead to increased dose enhancement.

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“…Os estudos na área de nanotecnologia estão em amplo crescimento, assim como para tratamentos em tumores malignos utilizando nanopartículas de alto número atômico (Z) [6][7][8]. A interação da radiação com essas partículas aumenta significativamente a produção de inúmeras partículas secundárias, como por exemplo, os elétrons Auger e raios delta (δ), que contribuem para o crescimento de dose e efeitos deletérios da radiação na região tumoral [9]. O uso dos códigos Monte Carlo vem sendo cada vez mais requisitados para estudos da compreensão e validação de pesquisas na área [9][10][11][12][13][14].…”

Section: Introductionunclassified

Cálculo Do Fator De Crescimento De Dose Devido À Adição De Partículas De Ouro Em Amostras Celulares Utilizando Simulação Computacional Monte Carlo

Araújo¹,

Geraldo²,

Valencia³

et al. 2023

Anais Da Semana Nacional De Engenharia Nuclear E Da Energia E Ciências Das Radiações

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A detailed experimental and Monte Carlo analysis of gold nanoparticle dose enhancement using 6 MV and 18 MV external beam energies in a macroscopic scale

Cited by 12 publications

References 48 publications

Experimental benchmark data for Monte Carlo simulated radiation effects of gold nanoparticles. Part I: Experiment and raw data analysis

Experimental benchmark data for Monte Carlo simulated radiation effects of gold nanoparticles. Part I: Experiment and raw data analysis

Depth Dose Enhancement in Orthovoltage Nanoparticle-Enhanced Radiotherapy: A Monte Carlo Phantom Study

Cálculo Do Fator De Crescimento De Dose Devido À Adição De Partículas De Ouro Em Amostras Celulares Utilizando Simulação Computacional Monte Carlo

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