A detailed Monte Carlo accounting of radiation transport in the brain during BNCT

Chin, M.; Spyrou, N. M.

doi:10.1016/j.apradiso.2009.03.040

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…To simplify the calculation, only some reactions cross sections are chosen: (n,n), (n,␣) (n,p) and (n,␥). 27 This is a realistic hypothesis because other reactions are not frequent with the specific energy of atmospheric neutrons, their cross sections being too low. The simulation is done with the Visual-Basic programming language and the ENDF/B library.…”

Section: Modelling Methodologymentioning

confidence: 99%

Therapeutic potential of atmospheric neutrons

Voyant

Roustit²,

Tatje³

et al. 2011

Reports of Practical Oncology & Radiotherapy

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It has been shown that BNCT may be used with a natural source of neutrons, and may potentially be useful for the treatment of micro-metastases. The atmospheric neutron flux is much lower than that utilized during standard NBCT. However the purpose of the proposed study is not to replace the ordinary NBCT but to test if naturally occurring atmospheric neutrons, considered to be an ionizing pollution at the Earth's surface, can be used in the treatment of a disease such as cancer. To finalize this study, it is necessary to quantify the biological effects of the physically deposited dose, taking into account the characteristics of the incident particles (alpha particle and Lithium atom) and radio-induced effects (by-stander and low dose effect). One of the aims of the presented paper is to propose to experimental teams (which would be interested in studying the phenomena) a simple way to calculate the dose deposition (allometric fit of free path, transmission factor of brain).

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Section: Modelling Methodologymentioning

confidence: 99%

Therapeutic potential of atmospheric neutrons

Voyant

Roustit²,

Tatje³

et al. 2011

Reports of Practical Oncology & Radiotherapy

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“…The Monte Carlo method is utilized for RT dose calculation. Unlike conventional dose planning algorithms, the Monte Carlo method takes into consideration the influence of inhomogeneities on dose delivered by primary radiation as well as scattered radiation [46]. This makes it appropriate from the BNCT standpoint where the dose contribution is from different by-products of nuclear fission reactions and contaminants in low-energy neutron beams from nuclear reactors.…”

Section: Treatment Planningmentioning

confidence: 99%

Radiobiology of Combining Radiotherapy with Other Cancer Treatment Modalities

Ahire,

Ahmadi Bidakhvidi,

Boterberg

et al. 2023

Radiobiology Textbook

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In this chapter, we address the role of radiation as treatment modality in the context of oncological treatments given to patients. Physical aspects of the use of ionizing radiation (IR)—by either photons, neutrons, or charged (high linear energy transfer) particles—and their clinical application are summarized. Information is also provided regarding the radiobiological rationale of the use of conventional fractionation as well as alternative fractionation schedules using deviating total dose, fraction size, number of fractions, and the overall treatment time. Pro- and contra arguments of hypofractionation are discussed. In particular, the biological rationale and clinical application of Stereotactic Body Radiation Therapy (SBRT) are described. Furthermore, background information is given about FLASH radiotherapy (RT), which is an emerging new radiation method using ultra-high dose rate allowing the healthy, normal tissues and organs to be spared while maintaining the antitumor effect. Spatial fractionation of radiation in tumor therapy, another method that reduces damage to normal tissue is presented. Normal tissue doses could also be minimized by interstitial or intraluminal irradiation, i.e., brachytherapy, and herein an overview is given on the principles of brachytherapy and its clinical application. Furthermore, details are provided regarding the principles, clinical application, and limitations of boron neutron capture therapy (BNCT). Another important key issue in cancer therapy is the combination of RT with other treatment modalities, e.g., chemotherapy, targeted therapy, immunotherapy, hyperthermia, and hormonal therapy. Combination treatments are aimed to selectively enhance the effect of radiation in cancer cells or to trigger the immune system but also to minimize adverse effects on normal cells. The biological rationale of all these combination treatments as well as their application in clinical settings are outlined. To selectively reach high concentrations of radionuclides in tumor tissue, radioembolization is a highly interesting approach. Also, radioligand therapy which enables specific targeting of cancer cells, while causing minimal harm surrounding healthy tissues is presented. A brief overview is provided on how nanotechnology could contribute to the diagnosis and treatment of cancer. Last but not least, risk factors involved in acquiring secondary tumors after RT are discussed.

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“…Para investigar la interacción de la radiación ionizante en el paciente y calcular la dosis absorbida en tejidos sanos y tumorales se usa el método Monte Carlo con base en diferentes códigos, los cuales proporcionan información detallada de distribución de dosis [8]. El paquete PENELOPE simula el transporte de electrones, fotones y positrones en materiales arbitrarios y permite el uso de valores de energía de 100 eV a 1 GeV, en geometrías y materiales definidos por el usuario [9].…”

Section: Introductionunclassified

Monte Carlo Simulation of 6, 10 and 18 Mv Photon Beam Dose Distribution in a Brain Tumor

Gonzales Ccoscco,

Guzmán-Calcina,

Vega-Ramírez

2023

Momento

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This study aimed to obtain the absorbed dose distribution in a heterogeneous head simulator object where a brain tumor of 2 cm in diameter was located. Materials equivalent to the head and tumor were created. For head and tumor simulation, elemental composition (H, C, N, O, and others) and mass density ρ respectively were used. X-ray spectra of 6, 10 and 18 MV were used for the exposures, projecting a field of 3×3 cm2 to the tumor, with an isocentric source distance of 100 cm. Monte Carlo simulations were done with PENELOPE v.2008 code. The results show that the maximum dose to the skin is 32 %, 20 % and 14 %, the maximum dose to the skull is 88 %, 74 % and 62 %, and the maximum dose to the tumor is 62 %, 67% and 73 %, for energies of 6, 10 and 18 MV respectively. The maximum dose received by the skin and skull tissues decreases with increasing energy, while the dose in the tumor increases with increasing energy.

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A detailed Monte Carlo accounting of radiation transport in the brain during BNCT

Cited by 5 publications

References 11 publications

Therapeutic potential of atmospheric neutrons

Therapeutic potential of atmospheric neutrons

Radiobiology of Combining Radiotherapy with Other Cancer Treatment Modalities

Monte Carlo Simulation of 6, 10 and 18 Mv Photon Beam Dose Distribution in a Brain Tumor

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