A developmental model for similarities and dissimilarities between schizophrenia and bipolar disorder

Murray, Robin M.; Sham, Pak C.; Os, Jim van; Zanelli, Jolanta; Cannon, Mary; McDonald, Colm

doi:10.1016/j.schres.2004.03.002

Cited by 459 publications

(374 citation statements)

References 108 publications

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“…A neurodevelopmental model has been proposed for schizophrenia with the notion that early insults in the brain could impair neurocognitive development. 33 The remaining two suggestive regions identified in this study contain genes involving the ion channel transport. The rs2073831 SNP locates between BTF3L1 and KCTD12, however, the role of BTF3L1, a hypothetical basic transcription factor 3, like 1, has no obvious connection to the pathogenesis of bipolar I disorder.…”

Section: Discussionmentioning

confidence: 77%

Genome-wide association study of bipolar I disorder in the Han Chinese population

et al. 2010

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We report the first genome-wide association study in 1000 bipolar I patients and 1000 controls, with a replication of the top hits in another 409 cases and 1000 controls in the Han Chinese population. Four regions with most strongly associated single-nucleotide polymorphisms (SNPs) were detected, of which three were not found in previous GWA studies in the Caucasian populations. Among them, SNPs close to specificity protein 8 (SP8) and ST8 a-Nacetyl-neuraminide a-2,8-sialyltransferase (ST8SIA2) are associated with Bipolar I, with Pvalues of 4.87 Â 10 À7 (rs2709736) and 6.05 Â 10 À6 (rs8040009), respectively. We have also identified SNPs in potassium channel tetramerization domain containing 12 gene (KCTD12) (rs2073831, P = 9.74 Â 10 À6 ) and in CACNB2 (Calcium channel, voltage-dependent, b-2 subunit) gene (rs11013860, P = 5.15 Â 10 À5 ), One SNP nearby the rs1938526 SNP of ANK3 gene and another SNP nearby the SNP rs11720452 in chromosome 3 reported in previous GWA studies also showed suggestive association in this study (P = 6.55 Â 10 À5 and P = 1.48 Â 10 À5 , respectively). This may suggest that there are common and population-specific susceptibility genes for bipolar I disorder.

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Section: Discussionmentioning

confidence: 77%

Genome-wide association study of bipolar I disorder in the Han Chinese population

et al. 2010

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“…However, our results suggest the AKT1 effect to be general in nature, and underscore the possibility that AKT1 plays a role in multiple psychiatric syndromes. Although clear differences exist between schizophrenia and bipolar disorder (52), neuropharmacological studies implicate dopamine dysregulation in both, and molecular studies suggest the conditions may share predisposing genes (53).…”

Section: Discussionmentioning

confidence: 99%

AKT1 Is Associated with Schizophrenia Across Multiple Symptom Dimensions in the Irish Study of High Density Schizophrenia Families

Thiselton

Vladimirov²,

Kuo³

et al. 2008

Biological Psychiatry

151

111

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Background-The phosphatidylinositol 3-kinase (PI3K)-AKT signal transduction pathway is critical to cell growth and survival. In vitro functional studies indicate that the candidate schizophrenia susceptibility gene DTNBP1 influences AKT signaling to promote neuronal viability. The AKT1 gene has also been implicated in schizophrenia by association studies and decreased protein expression in the brains of schizophrenic patients.

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“…Early hypoxia would cause an abnormal brain development during childhood (Haukvik et al, 2012), and, in support of this hypothesis, hippocampus, basal ganglia and amygdala atrophy have been found more frequently in schizophrenic patients with obstetric complications than in patients without perinatal insults (Murray et al, 2004;Morales et al, 2011). Moreover poor treatment response has been reported in schizophrenia patients with a history of obstetric complications (Alvir et al, 1999).…”

Section: Introductionmentioning

confidence: 95%

Are obstetrical complications really involved in the etiology and course of schizophrenia and mood disorders?

Buoli

Bertino

Caldiroli

et al. 2016

Psychiatry Research

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The impact of stressful experiences during gestation or early life, leading to increased psychiatric disorders susceptibility, is currently well described in literature, however, few data are available on the association between obstetrical complications and later development of specific diagnoses or clinical features (e.g. psychotic symptoms). Aim of the present paper was to evaluate obstetrical complications frequency in different psychiatric diagnoses and their association with clinical features. Three hundred and eighty-eight patients with a diagnosis of schizophrenia, bipolar disorder or major depressive disorder were compared in terms of clinical presentation according to the presence, type and severity of obstetrical complications. Seventeen percent of the total sample (N=65) had history of at least one obstetrical complication. Patients with a history of at least one obstetrical complication result in an earlier age of onset (F=3.93, p=0.04) and a current higher GAF score (F=6.46, p=0.01). Lewis-Murray scale score was directly correlated with GAF scores (t=2.9, p=0.004) and inversely correlated with age at onset (t=-2.77, p=0.006). Obstetrical complications are frequently registered in patients with schizophrenia or mood disorders. In our sample, they appear to have an anticipatory effect on illness onset, but they seem not to be associated with a specific psychiatric diagnosis.

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A developmental model for similarities and dissimilarities between schizophrenia and bipolar disorder

Cited by 459 publications

References 108 publications

Genome-wide association study of bipolar I disorder in the Han Chinese population

Genome-wide association study of bipolar I disorder in the Han Chinese population

AKT1 Is Associated with Schizophrenia Across Multiple Symptom Dimensions in the Irish Study of High Density Schizophrenia Families

Are obstetrical complications really involved in the etiology and course of schizophrenia and mood disorders?

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