A device for intranasal drug delivery for sedation in pediatric patients

Dubey, Prakash K.; Dubey, Niyati

doi:10.1111/pan.13799

Cited by 3 publications

(2 citation statements)

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“…The procedure was repeated on the opposite nostril. Intranasal spray was given by insulin syringe to administer the treatment (lig nocaine spray and conventional saline spray) [10]. Lignocaine and saline were loaded in the insu lin syringe and the swabs were prepared by an independent clinician not involved in the study.…”

Section: Study Randomization and Interventionmentioning

confidence: 99%

“…Using a lignocaine nasal spray, a modified version of the technique de scribed above has been published and found to be effective in attaining this objective [9]. As the gan glion is known to be blocked by surface application of lignocaine, a nasal spray is a less invasive and less intimidating alternative [9,10]. The use of lignocaine spray for intranasal sphenopalatine ganglion block following spinal anesthesia for postdural punc ture headache has not been extensively explored.…”

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confidence: 99%

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Intranasal sphenopalatine ganglion block by lignocaine spray for postdural puncture headache following spinal anesthesia: a randomized clinical trial

Smita,

Dubey,

Singh

2023

ait

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Background:In a randomized clinical study, we investigated the effectiveness of nasal lignocaine spray and swabs in treating postdural puncture headache (PDPH) after spinal anesthesia.Methods: Group S patients received two puffs of lignocaine 10% spray in both nostrils followed by cotton soaked in normal saline, and group B patients received two puffs of saline spray in both nostrils followed by a cotton swab soaked in lignocaine 2%. Patients were assessed before the procedure and 30 minutes, 60 minutes, 2 h, 24 h, 48 h, and 72 h after the procedure for pain relief with the help of a visual analogue scale (VAS). Hemodynamic parameters and adverse effects were also recorded. Normally distributed continuous variables were expressed as mean (95% confidence interval) whereas non-normally distributed variables were expressed as median (IQR). Repeated measures analysis of variance was used to compare the VAS score at different time points between test and control groups. The difference in means between the two groups was compared using the independent sample t-test. The paired t-test was used to compare the changes in clinical and laboratory variables.Results: At each time point, the mean VAS score for pain was substantially different between the two groups. Moreover, until the second hour, the VAS score was significantly lower in group S than in group B. No significant intervention-related adverse effect was observed in either group. Conclusions:Without any noticeable side effects, lignocaine 10% spray is more successful in treating PDPH after spinal anesthesia, particularly in the first two hours.

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Section: Study Randomization and Interventionmentioning

confidence: 99%

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confidence: 99%