A diagnostic score for the irritable bowel syndrome

Kruis, Wolfgang; Thieme, Ch.; Weinzierl, M; Schüssler, P; Holl, Joseph; Paulus, Walter J.

doi:10.1016/0016-5085(84)90119-7

Cited by 235 publications

(19 citation statements)

References 14 publications

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“…Like FMS, IBS is more common in women than in men, both among non-patients [24] and those who seek medical help [25]. Interestingly, Gwee [26] recently reported equal male: female occurrence of acute gastroenteritis, but subsequently more female (77%) than male (36%) developed IBS.…”

Section: Irritable Bowel Syndromementioning

confidence: 97%

The role of gender in fibromyalgia syndrome

Yunus

2001

Curr Rheumatol Rep

136

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Fibromyalgia syndrome (FMS), characterized by widespread pain and tenderness on palpation (tender points), is much more common in women than in men in a proportion of 9:1. Two recent studies have shown important gender differences in various clinical characteristics of FMS. In a community and a clinic sample, women experienced significantly more common fatigue, morning fatigue, hurt all over, total number of symptoms, and irritable bowel syndrome. Women had significantly more tender points. Pain severity, global severity and physical functioning were not significantly different between the sexes, nor were psychologic factors, eg, anxiety, stress, and depression. Gender differences have also been observed in other related syndromes, eg, chronic fatigue syndrome, irritable bowel syndrome, and headaches. The mechanisms of gender differences in these illnesses are not fully understood, but are likely to involve an interaction between biology, psychology, and sociocultural factors.

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Section: Irritable Bowel Syndromementioning

confidence: 97%

The role of gender in fibromyalgia syndrome

Yunus

2001

Curr Rheumatol Rep

136

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“…However, when these symptoms and simple laboratory findings were evaluated to estimate their relative diagnostic value, the most heavily weighed items were found to be those pathognomonic for non-functional diseases [8]. However, when these symptoms and simple laboratory findings were evaluated to estimate their relative diagnostic value, the most heavily weighed items were found to be those pathognomonic for non-functional diseases [8].…”

Section: Introductionmentioning

confidence: 95%

“…Some symptoms such as abdominal pain preceeding evacuation, abdominal distension, irregularity of bowel pattern, sense of incomplete evacuation and mucus in the stool have consistently been shown to be associated with IBS. However, when these symptoms and simple laboratory findings were evaluated to estimate their relative diagnostic value, the most heavily weighed items were found to be those pathognomonic for non-functional diseases [8]. Thus, the diagnosis of IBS still largely depends on the exclusion of underlying organic disease [9].…”

Section: Introductionmentioning

confidence: 99%

Seeking clues for a positive diagnosis of the irritable bowel syndrome

Vernia¹,

Latella²,

Magliocca³

et al. 1987

Eur J Clin Investigation

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Despite its high prevalence the irritable bowel syndrome (IBS) lacks acceptable pathophysiological markers and its diagnosis largely depends on the exclusion of underlying organic disease. Systemic acid-base balance, serum electrolytes and the composition of faecal water (electrolytes and organic anions), were studied in thirty-eight diarrhoeal patients out of a series of ninety-three consecutive IBS patients. Only patients with diarrhoea as the predominant symptom were included in the study to evaluate whether this subgroup could provide the clue for a positive diagnosis of the syndrome. Serum electrolytes and systemic acid-base balance were within the normal range. Faecal electrolytes were also normal (Na 26.6 +/- 19.3 SD; K 66.8 +/- 28.3; Cl 19.1 +/- 15.2 mEq 1(-1)), despite the finding of a moderately increased 24-h faecal output. The K:Na ratio was also within the normal range. These data are in agreement with the lack of systemic changes observed in IBS patients even with profuse or longstanding diarrhoea. Both faecal short chain fatty acids and lactic acid were increased in patients vs. controls, but a considerable overlap with normal values was observed (131.4 +/- 62.6 SD vs. 108.5 +/- 58.3 mEq 1(-1). Only lactic acid concentration was significantly higher than in controls (1.3 +/- 1.2 vs. 0.5 +/- 0.2). Despite these findings it is concluded that the subgroup of IBS patients with diarrhoea also appears to lack a pathophysiological marker and does not provide clues for a positive diagnosis of this syndrome.

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“…Ten patients met the criteria of irritable bowel syndrome as established by Kruis et al 5 Exclusion of organic disease was assumed after upper and lower gastrointestinal endoscopy and different serum and stool parameters without any abnormalities. All IBS patients investigated had stool disorders like chronic or recurrent chronic diarrhea or alteration of constipation and diarrhea.…”

Section: Methodsmentioning

confidence: 99%