A diet of somatic cell nuclear transfer cloned‐cattle meat produced no toxic effects on behavioral or reproductive characteristics of F1 rats derived from dams fed on cloned‐cattle meat

Yang, Byoung-Chul; Lee, Nam-Jin; Im, Gi‐Sun; Seong, Hwan‐Hoo; Park, Jin-Ki; Kang, Jong-Koo; Hwang, Seongsoo

doi:10.1002/bdrb.20309

Cited by 7 publications

(2 citation statements)

References 33 publications

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“…In the studies, no harmful effects of the diet were observed in female (estrus cycle, implantation, fertility, delivery, external findings, necropsy findings, and physiological development) or male (weight of epididymis and testis, epididymal sperm motility, morphology, and sperm counts) reproductive parameters in both laboratory animals and their offspring. Furthermore, no mutagenic toxicity (bacterial mutation, chromosome aberration, and micronucleus genotoxicity), F1 behavioral toxicity (sensory reflex, motor function, spatial learning, and memory tests), or reproductive toxicity (mating, fertility, and implantation) was detected in the animal fed diets containing cloned cattle-derived meat (Lee et al 2011; Yang et al 2011).…”

Section: Discussionmentioning

confidence: 99%

No Long-term Feeding Toxicities on the Health Status in Rats Fed with Cloned Korean Native Beef Cattle (Hanwoo) Meat

Lee

Yang

et al. 2012

Toxicol Pathol

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This study was designed to undertake a risk assessment to identify the health status of rats fed with somatic cell nuclear transfer (SCNT)-cloned Korean native beef cattle (Hanwoo) meat for 26 weeks. The rats were randomly divided into 5 groups, each consisting of 12 male (142.6 + 5.23 g) and 12 female (113.7 + 6.31 g) rats each. The animals were fed commercial pellets (control), pellets containing 5% (N-5) and 10% (N-10) of normal cattle meat, and diets containing 5% (C-5) and 10% (C-10) of cloned cattle meat. The mortality; clinical signs; body weight; food consumption; urinary, hematology, blood biochemistry, and histopathological analyses; and absolute and relative organ weights were analyzed and compared. During the 26-week test period, health status-related factors of the rats fed on cloned Hanwoo meat were found to have no test substancerelated toxicities. The only difference was the increased uterus weight in female C-10 rats as compared to their counterparts counterparts (p < .05). On the basis of these health status results, it can be postulated that no food consumption risks might arise from the long-term feeding of cloned cattle meat in rats.

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Section: Discussionmentioning

confidence: 99%

No Long-term Feeding Toxicities on the Health Status in Rats Fed with Cloned Korean Native Beef Cattle (Hanwoo) Meat

Lee

Yang

et al. 2012

Toxicol Pathol

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“…The effects on the behavioural and reproductive characteristics of F1 rats derived from dams fed during pregnancy a diet supplemented with SCNT cattle meat were investigated by Yang et al (2011). F1 rats were divided into five diet groups with their dams: commercial pellets (control), pellets containing 5% (N-5) and 10% (N-10) of conventional-cattle meat, and diets containing 5% (C-5) and 10% (C-10) of clone meat.…”

Section: Toxicity and Reproduction Studiesmentioning

confidence: 99%

Update on the state of play of Animal Health and Welfare and Environmental Impact of Animals derived from SCNT Cloning and their Offspring, and Food Safety of Products Obtained from those Animals

2012

EFS2

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<p>The European Food Safety Authority (EFSA) received in December 2011, a request from the European Commission for an update on the possible scientific developments for cloning of farmed animals for food production purposes. The present Statement follows the EFSA 2009 and 2010 Statements and the EFSA 2008 Scientific Opinion, and is based on peer reviewed scientific literature published since the EFSA 2010 Statement, information made available to EFSA following a call for data, and discussions with experts in the field of animal cloning. As reported before, Somatic Cell Nuclear Transfer (SCNT) can produce healthy clones, but a portion of the animal clones suffered from developmental abnormalities likely due to epigenetic dysregulation (incomplete nuclear programming) and died at various stages of development. For some of the live animal clones, in particular calves and piglets, health and welfare were compromised specifically within the perinatal and juvenile period. Also some of the surrogate dams were affected due to abnormal pregnancies. Food products from healthy clones, i.e. meat or milk, did not differ from products from healthy conventionally bred animals. The offspring of clones and their food products showed no differences with conventional offspring or products. Data on clones of farmed species for food production other than cattle and pigs have remained limited and do not allow for the assessment of food safety or animal health and welfare aspects. The cloning efficiency, defined as the number of live offspring as a proportion of the number of transferred embryos, remained about 6-15 % for cattle and about 6 % for pigs. When compared with <em>in vitro</em> fertilisation (IVF), for which the background percentage of live offspring per transferred embryo is 45-60%, the efficiency of cattle SCNT relative to IVF is 13-25%. To overcome the relatively low cloning efficiency researchers continue to amend cloning procedures, with limited improvements shown by some researchers.</p>

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A Historical Perspective of the Cloning of Cattle

Kent‐First¹,

Beyhan

Ambroggio

et al. 2014

Principles of Cloning

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A diet of somatic cell nuclear transfer cloned‐cattle meat produced no toxic effects on behavioral or reproductive characteristics of F1 rats derived from dams fed on cloned‐cattle meat

Abstract: These behavioral and reproductive toxicity results suggest that there are no obvious food safety concerns related to cloned-cattle meat in these parameters.

Cited by 7 publications

References 33 publications

No Long-term Feeding Toxicities on the Health Status in Rats Fed with Cloned Korean Native Beef Cattle (Hanwoo) Meat

No Long-term Feeding Toxicities on the Health Status in Rats Fed with Cloned Korean Native Beef Cattle (Hanwoo) Meat

Update on the state of play of Animal Health and Welfare and Environmental Impact of Animals derived from SCNT Cloning and their Offspring, and Food Safety of Products Obtained from those Animals

A Historical Perspective of the Cloning of Cattle

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