A Dietary Carbohydrate – Gut Parasutterella – Human Fatty Acid Biosynthesis metabolic axis in obesity and type 2 diabetes

Henneke, Lea; Schlicht, Kristina; Andreani, Nadia Andrea; Hollstein, Tim; Demetrowitsch, Tobias; Knappe, Carina; Hartmann, Katharina; Jensen-Kroll, Julia; Rohmann, Nathalie; Pohlschneider, Daniela; Geisler, Corinna; Schulte, Dominik M; Settgast, Ute; Türk, Kathrin; Zimmermann, Johannes; Kaleta, Christoph; Baines, John F.; Shearer, Jane; Shah, Saleh; Shen–Tu, Grace; Schrieber, Karin; Franke, André; Schreiber, Stefan; Laudes, Matthias

doi:10.1055/s-0042-1746345

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Amino Acids and Amines1

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2022

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“…The abundance of Parasutterella sp. is negatively related to the serum concentration of cysteine, and is significantly downregulated in weight-loss-obesity patients (120). Methionine biosynthesis mediated by gut microbiota is associated with atherosclerosis in obese children (121).…”

Section: Amino Acids and Aminesmentioning

confidence: 99%

Roles of gut microbiota and metabolites in overweight and obesity of children

Zhang

Dang

2022

Front. Endocrinol.

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The prevalence of overweight and obesity in children and adolescents is an increasing public health problem. Pediatric overweight and obesity result from multiple factors, including genetic background, diet, and lifestyle. In addition, the gut microbiota and their metabolites play crucial roles in the progression of overweight and obesity of children. Therefore, we reviewed the roles of gut microbiota in overweight/obese children. The relationship between pediatric overweight/obesity and gut metabolites, such as short-chain fatty acids, medium-chain fatty acids, amino acids, amines, and bile acids, are also summarized. Targeting gut microbiota and metabolites might be a promising strategy for interventions aimed at reducing pediatric overweight/obesity.

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Section: Amino Acids and Aminesmentioning

confidence: 99%