A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins

Cerbo, Alessandro Di; Laurino, Carmen; Palmieri, Beniamino; Iannitti, Tommaso

doi:10.1016/j.jphotobiol.2014.12.025

Cited by 40 publications

(35 citation statements)

References 72 publications

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“…Blood contains several kinds of extracellular matrix proteins, such as fibronectin, fibrinogen, type IV collagen, vitronectin, and elastin, all of which except fibrinogen are contained in both plasma and serum (39)(40)(41). It has been reported that some of the cell surface proteins of S. aureus bind and aggregate following interaction with extracellular matrix proteins in the blood (42,43).…”

Section: Discussionmentioning

confidence: 99%

Contribution of Streptococcus mutans Strains with Collagen-Binding Proteins in the Presence of Serum to the Pathogenesis of Infective Endocarditis

et al. 2017

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Streptococcus mutans, a major pathogen of dental caries, is considered one of the causative agents of infective endocarditis (IE). Recently, bacterial DNA encoding 120-kDa cell surface collagen-binding proteins (CBPs) has frequently been detected from S. mutans-positive IE patients. In addition, some of the CBP-positive S. mutans strains lacked a 190-kDa protein antigen (PA), whose absence strengthened the adhesion to and invasion of endothelial cells. The interaction between pathogenic bacteria and serum or plasma is considered an important virulence factor in developing systemic diseases; thus, we decided to analyze the pathogenesis of IE induced by S. mutans strains with different patterns of CBP and PA expression by focusing on the interaction with serum or plasma. CBP-positive (CBP ϩ )/PA-negative (PA Ϫ ) strains showed prominent aggregation in the presence of human serum or plasma, which was significantly greater than that with CBP ϩ /PA-positive (PA ϩ ) and CBP-negative (CBP Ϫ )/PAϩ strains. Aggregation of CBP ϩ /PA Ϫ strains was also observed in the presence of a high concentration of type IV collagen, a major extracellular matrix protein in serum. In addition, aggregation of CBP ϩ /PA Ϫ strains was drastically reduced when serum complement was inactivated. Furthermore, an ex vivo adherence model and an in vivo rat model of IE showed that extirpated heart valves infected with CBP ϩ /PA Ϫ strains displayed prominent bacterial mass formation, which was not observed following infection with CBP ϩ /PA ϩ and CBP Ϫ /PA ϩ strains. These results suggest that CBP ϩ /PA Ϫ S. mutans strains utilize serum to contribute to their pathogenicity in IE. KEYWORDS Streptococcus mutans, blood, infective endocarditisG ram-positive cocci, such as Staphylococcus aureus and viridans group streptococci, are major pathogens in infective endocarditis (IE) (1, 2). One of the important steps for the pathogenesis of IE is invasion of pathogenic bacteria into the bloodstream (1). Viridans group streptococci invade the bloodstream following professional dental treatment as well as routine daily oral care (3, 4) and are associated with a risk for IE in subjects with underlying heart disorders, though these bacteria are predominantly phagocytosed and eliminated in healthy humans (5).Streptococcus mutans, classified as a viridans group streptococcus, is a major pathogen of dental caries and is occasionally isolated from the blood of IE patients (6). In 1993, approximately 10 to 20% of S. mutans strains were demonstrated to possess collagen-binding activity, which was regarded to be advantageous for binding to collagenous tissue, such as dentin (7). Thereafter, 120-kDa collagen-binding proteins (CBPs), which were classified as Cnm and Cbm, were identified on the cell surfaces of some S. mutans strains in 2004 and 2012, respectively (8, 9).

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Section: Discussionmentioning

confidence: 99%

Contribution of Streptococcus mutans Strains with Collagen-Binding Proteins in the Presence of Serum to the Pathogenesis of Infective Endocarditis

et al. 2017

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“…Furthermore, the diagnostic device encompasses impedance variation as related to intracellular and interstitial water content. Therefore, total, extracellular and intracellular water can be detected [23].…”

Section: Thickness Of the Stratum Corneum (Sct)mentioning

confidence: 99%

Genetic Customization of Anti-aging Treatments

Nisticò¹,

Duca²,

Garoia³

2018

J Clin Exp Dermatol Res

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Skin aging is a multifactorial process that involves both intrinsic factors of genetic and hormonal origin and extrinsic factors of environmental and nutritional nature.The purpose of this open study on a case series of volunteers is to evaluate the impact of genetic customization of common anti-aging dermocosmetic treatments. We report how the treatment may be customized by acting selectively on the metabolic impairments identified by the analysis of specific DNA variants. The customized cosmetic method shows a significantly higher efficacy compared to non-specific cosmetic treatments such as radiofrequency, suggesting that the combination genetic signature may provide a useful tool for personalized and more effective anti-aging therapies.

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“…Modulation of these parameters by the dietary supplementation may be useful to counteract some of the age-related dermatological changes, accordingly with previous findings, where the same supplement significantly improved VAS photoaging score, facial sebum, hydration and tonicity from the second week of treatment. 24 Collagen was added into the formula since experimental evidences from murine models has shown that: if adequately orally administered it prevents UV radiationinduced skin damage. 35,36 In a study by Proksch et al, oral supplementation of collagen hydrolysate composed of specific collagen peptides (2.5 g/d or 5.0 g/d for 8 weeks) increased skin elasticity in middle-aged women after 4 weeks of supplementation.…”

Section: Discussionmentioning

confidence: 99%

“…24 The object of this second study is to confirm that this supplement affects several skin face parameters [i.e. hydration, trans epidermal water loss (TEWL) and elasticity] and to confirm the hypothesis that it can also improves nails hardness, hair loss and hair breakage in patients affected by age-related dermatological changes.…”

Section: Introductionmentioning

confidence: 93%

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A dietary supplement improves age-related dermatological changes. Observational, anecdotal, spontaneous study.

et al. 2017

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Skin ageing involves also its annexes, such as hair and nails. Hair follicles are produced during embryogenesis. 1 In the postnatal life, hair follicle grows through three distinct phases: (i) anagen (growth) phase; (ii) catagen (regressing) phase; and (iii) telogen (resting) phase.2 This puzzling selfrenewal property is maintained by the stem cell niche located in the bulge portion of the hair follicle. 3 The hair follicle has a highly complex structure with eight distinct cell layers. The nail is hard keratin adnexa, produced by the same germinative epithelium and process through which epidermal skin cells produce the stratum corneum. Nail keratinocytes contribute to cornification through the production of hard keratins and the hardness of the nail plate is due to a high concentration of sulfur matrix protein. 4The rate of people with significant dermis and epidermis disorders increases linearly with age: at 70 years about 70% of the population claims at least one related-skin problem. 5The loss of hydration, appearance of fine wrinkles, roughness, dryness, thickening, laxity, telangiectasia, and loss of tensile strength are common features of the A B S T R A C T ORIGINAL ARTICLE ASIAN JOURNAL OF MEDICAL SCIENCESBackground: The rate of people with significant dermis and epidermis disorders increases linearly with age. The majority of skin changes are a consequence of cumulative exposure to environmental factors, such as chronic ultraviolet exposure. Aims and Objectives: Age-related dermatological changes include skin laxity, nails fragility, hair loss and hair breakage. This spontaneous, anecdotal observational study investigates if a dietary supplementation based on collagen, chondroitin sulfate, low-molecular weight hyaluronic acid, Pycnogenol® and coenzyme Q10 can improve age-related dermatological changes. Materials and Methods: Thirty four patients received the dietary supplement for 2 times/daily for 12 weeks. Facial skin hydration, Trans Epidermal Water Loss (TEWL) and elasticity were assessed at baseline and after 12 weeks in five selected areas. Nails hardness of the index, middle and ring fingers were also assessed at baseline and at followup by a durometer and by a nail score. The Hair Mass Index (HMI) and the Hair Breakage Index (HBI) were assessed by a mechanical device together with hair score at baseline and after 12 weeks. Results: After 12 weeks skin hydration, TEWL and elasticity significantly improved in all the tested areas (p < 0.01 and p < 0.001). Nails hardness of index, middle and ring finger significantly increased (p < 0.001) after 12 weeks. HMI and HBI were both significantly reduced (p < 0.0001) after 12 weeks. In addition, both nails and hair score improved. Conclusions: Dietary supplementation significantly improved age-related dermatological changes.

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A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins

Cited by 40 publications

References 72 publications

Contribution of Streptococcus mutans Strains with Collagen-Binding Proteins in the Presence of Serum to the Pathogenesis of Infective Endocarditis

Contribution of Streptococcus mutans Strains with Collagen-Binding Proteins in the Presence of Serum to the Pathogenesis of Infective Endocarditis

Genetic Customization of Anti-aging Treatments

A dietary supplement improves age-related dermatological changes. Observational, anecdotal, spontaneous study.

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