A differential effect of yohimbine on adrenal and neuronal catecholamine release during bilateral carotid occlusion in the dog

Yamaguchi, Nobuharu; Brassard, Martine

doi:10.1016/0165-1838(88)90019-7

Cited by 7 publications

(1 citation statement)

References 26 publications

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“…Net renal noradrenaline output was determined and used as an index of local sympathetic nerve activity, a procedure that was recently validated (Bradley et al 1987;Yamaguchi & Brassard 1988). Following adrenal venous cannulation and the setup of an extra-corporeal circulation system as described above, a small flexible polyethylene catheter (Cathlon IV, 57 mm) was inserted directly into the left renal vein, the other end of the catheter being secured to the outer surface of the abdominal vena cava.…”

Section: Preparation For Renal Venous Catecholamine and Blood Flow Mementioning

confidence: 99%

Evidence That Increases in Circulating Catecholamines of Adrenal Origin Are Not Involved in Pressor Response to Bilateral Carotid Occlusion in Anaesthetized Dogs

Brassard

Yamaguchi

1989

Clin Exp Pharma Physio

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1. We studied whether or not circulating catecholamines of adrenal origin play a major role in cardiovascular responses evoked by bilateral carotid artery occlusion (3 min) in anaesthetized dogs. 2. In the control group, the following parameters increased significantly (P less than 0.05) during bilateral carotid occlusion: aortic systolic pressure, heart rate, net adrenal catecholamine output, net renal noradrenaline output, and plasma catecholamine concentrations in aortic blood. Similar responses were obtained during the second occlusion performed approximately 25 min after the first occlusion. 3. After functional adrenalectomy (ADRX: diversion of adrenal venous blood flow), the increase in aortic adrenaline concentration observed during bilateral carotid occlusion was abolished. The increase in aortic noradrenaline concentration during the occlusion was significantly attenuated by approximately 60% (P less than 0.01) after ADRX. 4. The increase in net renal noradrenaline output during bilateral carotid occlusion after ADRX was not different from that observed before ADRX. Similarly, the response of aortic systolic pressure and heart rate during the occlusion was unaffected by ADRX. Furthermore, the increase in net adrenal catecholamine output during the occlusion was not affected by ADRX itself. 5. From these results, we conclude that the increase in circulating catecholamines of adrenal origin during bilateral carotid occlusion is not a major determinant for the increases in aortic pressure and heart rate. The results suggest that these cardiovascular responses during the occlusion are mediated principally by neuronal noradrenaline released from peripheral sympathetic nerve terminals.

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Section: Preparation For Renal Venous Catecholamine and Blood Flow Mementioning

confidence: 99%

Evidence That Increases in Circulating Catecholamines of Adrenal Origin Are Not Involved in Pressor Response to Bilateral Carotid Occlusion in Anaesthetized Dogs

Brassard

Yamaguchi

1989

Clin Exp Pharma Physio

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Central Catecholamines and the Control of Sympathetic Tone

Goldstein¹

1992

Central Neural Mechanisms in Cardiovascular Regulation

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Effects of clonidine, dihydralazine and splanchnic nerve stimulation on the release of neuropeptide Y, MET-enkephalin and catecholamines from dog adrenal medulla

Damase‐Michel

Tavernier

Giraud

et al. 1993

Naunyn-Schmiedeberg's Arch Pharmacol

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Various neuropeptides are costored together with catecholamines in the adrenal medulla. The concurrent release (evaluated by adrenal vein plasma levels) of these neuropeptides [neuropeptide Y (NPY), met-enkephaline (ME)] and catecholamines [adrenaline (A) and noradrenaline (NA)] from the adrenal gland was examined in chloralose-anesthetized dogs after intravenous administration of clonidine (10 micrograms/kg) and dihydralazine (1 mg/kg). These results were compared to those obtained after the stimulation of the right splanchnic nerve at 1, 5 and 10 Hz frequencies. The increment in the release of catecholamines and neuropeptides was evaluated for dihydralazine and splanchnic nerve stimulation. Dihydralazine (at its maximal effect) induced a significant preferential increase in catecholamines (expressed as mean (SEM): NA: 17.3 (5.4) fold, A: 13.1 (2.6) fold) and ME (16.0 (7.1) fold) versus basal values. However, the significant increase in NPY-LI was only 2.0 (0.4) times the baseline. Splanchnic nerve stimulation induced a frequency-dependent increase in catecholamines and neuropeptides. When the stimulation frequency was increased from 1 Hz to 5 Hz, NA and A levels increased 17.9 (4.3) and 14.0 (2.2) fold, respectively and ME levels 14.1 (3.0) fold. By contrast, NPY-LI was increased only 2.3 (0.3) fold under the same conditions. Increasing the stimulation frequency from 5 Hz to 10 Hz resulted in similar elevations of NA, ME, and NPY-LI adrenal plasma levels (about 4 times) whereas A only increased twice. Clonidine decreased catecholamine and ME adrenal plasma levels (the maximal percent decrease when compared with control values was about 75%) whereas NPY adrenal plasma levels remained unchanged.(ABSTRACT TRUNCATED AT 250 WORDS)

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A differential effect of yohimbine on adrenal and neuronal catecholamine release during bilateral carotid occlusion in the dog

Cited by 7 publications

References 26 publications

Evidence That Increases in Circulating Catecholamines of Adrenal Origin Are Not Involved in Pressor Response to Bilateral Carotid Occlusion in Anaesthetized Dogs

Evidence That Increases in Circulating Catecholamines of Adrenal Origin Are Not Involved in Pressor Response to Bilateral Carotid Occlusion in Anaesthetized Dogs

Central Catecholamines and the Control of Sympathetic Tone

Effects of clonidine, dihydralazine and splanchnic nerve stimulation on the release of neuropeptide Y, MET-enkephalin and catecholamines from dog adrenal medulla

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