A differential-targeting core–shell microneedle patch with coordinated and prolonged release of mangiferin and MSC-derived exosomes for scarless skin regeneration

Lyu, Shang; Liu, Qi; Yuen, Ho-Yin; Xie, Huizhi; Yang, Yuhe; Yeung, Kelvin Wai-Kwok; Tang, Chak-yin; Wang, Shuqi; Liu, Yaxiong; Li, Bin; He, Yong; Zhao, Xin

doi:10.1039/d3mh01910a

Cited by 4 publications

(2 citation statements)

References 78 publications

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“…16 Currently, additional studies on exosome-loaded MNs are being actively conducted to find treatments for various diseases, such as spinal cord repair and skin regeneration. 17,18 However, studies on MNs loaded with preconditioned exosomes remain limited. Furthermore, MNs possess the ability to traverse the outermost layer of the oral mucosa, which facilitates the localized administration of pharmaceutical substances.…”

Section: Introductionmentioning

confidence: 99%

“…To overcome these issues, microneedle (MN) arrays, which offer painless, minimally invasive, and precisely controlled transdermal exosomes delivery, can be used. , Zhang et al successfully encapsulated MSC-exosomes in poly(vinyl alcohol) hydrogel MNs, which demonstrated excellent wound healing ability . Currently, additional studies on exosome-loaded MNs are being actively conducted to find treatments for various diseases, such as spinal cord repair and skin regeneration. , However, studies on MNs loaded with preconditioned exosomes remain limited. Furthermore, MNs possess the ability to traverse the outermost layer of the oral mucosa, which facilitates the localized administration of pharmaceutical substances …”

Section: Introductionmentioning

confidence: 99%

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Silk Fibroin Microneedles Loaded with Lipopolysaccharide-Pretreated Bone Marrow Mesenchymal Stem Cell-Derived Exosomes for Oral Ulcer Treatment

Ge,

Gao,

Zeng

et al. 2024

ACS Appl. Mater. Interfaces

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Oral ulcers, superficial lesions on the surface of the oral mucosa, have a high incidence rate, and their main symptoms include local pain and erosion. Lipopolysaccharide (LPS)preconditioned bone marrow mesenchymal stem cells and their secreted exosomes (LPS-pre-Exos) have been shown to promote recovery in various inflammatory conditions and wounds. However, studies documenting LPS-pre-Exos as a therapeutic intervention for oral mucosal-like diseases are lacking. In this study, we prepared a silk fibroin microneedle (MN) patch consisting of LPS-pre-Exos and zeolitic imidazolate framework-8 (ZIF-8) that localized at the tip and base, respectively, and used this MN patch for oral ulcer treatment. Upon insertion into the oral mucosa, continuous LPS-pre-Exos release was observed, which promoted macrophage polarization and tissue healing. Additionally, the ZIF-8 framework in the MN patch facilitated the controlled release of Zn 2+ , which demonstrated potent antimicrobial properties via synergistic effects. The in vitro experimental results showed that the silk fibroin MN patch can continuously release LPS-pre-Exos and Zn 2+ for more than 7 days. Thus, the LPS-pre-Exos and ZIF-8loaded silk fibroin MN patch exhibited good anti-inflammatory and antibacterial properties, promoting oral ulcer healing, and showed good histocompatibility. Hence, it may represent a potentially valuable strategy for facilitating oral ulcer healing.

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Section: Introductionmentioning

confidence: 99%