A digital cmos sequential circuit model for bio-cellular adaptive immune response pathway using phagolysosomic digestion: a digital phagocytosis engine

Hasan, S. M. Rezaul

doi:10.4236/jbise.2010.35065

Cited by 1 publication

(1 citation statement)

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“…Simulation of one whole-cell cycle of the smallest bacteria on earth, using an over simplified model, was run on a 128-node Linux cluster in 10 hours [6]. To overcome these issues an alternate direction in vogue nowadays is modeling of bio-cellular processes functionalities in specialized analog [2,[7][8], digital [9][10][11] or mixed IC electronic hardware [12][13]. The research work presented in this paper advocates analog transistor mimetics for bio-cellular processes as the bio-cellular processes and circuits are naturally more analog than digital; they are noisy and act in progressive way rather than stern off/on digital states [14][15].…”

Section: Introductionmentioning

confidence: 99%

Analog Electronic Circuits to Model Cooperativity in Hill Process

Waqas

Khurram

Hasan

2020

Mehran Univ. res. j. eng. technol.

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In the field of computational biology, electronic modeling of bio-cellular processes is in vogue for about a couple of decades. Fast, efficient and scalable electronic mimetics of recurrently found bio-chemical reactions are expected to provide better electronic circuit simulators that can also be used as bio-sensors or implantable biodevices at cellular levels. This paper presents some possible electronic circuit equivalents to model dynamics of one such bio-chemical reaction commonly involved in many bio-cellular processes, specifically pathways in living cells, known as the Hill process. The distinguishing feature of this process is cooperativity which has been modeled in silicon substrate using a pair of transistors, one transistor driving current in the other the same way ligand binding to one receptor site controls the binding affinity of the other receptor sites. Two possible circuits have been proposed and compared to electronically model cooperativity of a Hill reaction. The main idea is to exploit the natural analogies found between structures and processes of a bio-cell and electronic transistor mechanics, to efficiently model fundamental bio-chemical reactions found recurring in bio-processes. These circuits can then be combined and rearranged quickly to form larger, more complex bio-networks, thus mitigating the intricacies involved in modeling of such systems.

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