A dihydrochalcone and several homoisoflavonoids from Polygonatum odoratum are activators of adenosine monophosphate-activated protein kinase

Guo, Huanjie; Zhao, Huanxin; Kanno, Yuichiro; Li, Wei; Mu, Yuguang; Kuang, Xinzhu; Inouye, Yoshio; Koike, Kazuo; Jiang, Haipeng; Bai, Hong

doi:10.1016/j.bmcl.2013.04.027

Cited by 46 publications

(20 citation statements)

References 16 publications

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“…Previous investigations on the secondary metabolites of P. odoratum have reported A c c e p t e d M a n u s c r i p t 16 the existence of fourteen homoisoflavanones [35] and two phenylethylamides [36].…”

Section: Structural Elucidationmentioning

confidence: 98%

“…We examined the effects of all isolated compounds on α-glucosidase inhibition, and compounds (6)(7)(8)(9). Therefore, phenolic components (phenethyl cinnamides and homoisoflavanones) attributed to the α-glucosidase inhibitory activity of P.…”

Section: α-Glucosidase Inhibitory Activitymentioning

confidence: 99%

“…Homoisoflavonoids also can activate adenosine monophophate-activated protein kinase [7], and inhibit advanced glycation end product formation [8]. In addition, polysaccharides are found to reduce hyperglycemia caused by starch loading in normal and diabetic mice [9].…”

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Separation and purification of α-glucosidase inhibitors from Polygonatum odoratum by stepwise high-speed counter-current chromatography combined with Sephadex LH-20 chromatography target-guided by ultrafiltration–HPLC screening

Zhou

Liang

Zhang

et al. 2015

Journal of Chromatography B

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Section: Structural Elucidationmentioning

confidence: 98%

Section: α-Glucosidase Inhibitory Activitymentioning

confidence: 99%

See 1 more Smart Citation

Separation and purification of α-glucosidase inhibitors from Polygonatum odoratum by stepwise high-speed counter-current chromatography combined with Sephadex LH-20 chromatography target-guided by ultrafiltration–HPLC screening

Zhou

Liang

Zhang

et al. 2015

Journal of Chromatography B

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“…The absolute configuration of C-3 was determined to be R in accordance with the positive Cotton effect at 290-294 nm in the circular dichroism (CD) spectra. 10) Finally, the structure of compound 1 was elucidated as (3R)-2′,5-dihydroxy-4′,7-dimethoxy-6-methylhomoisoflavanone; named homoisopogon A.…”

Section: Resultsmentioning

confidence: 99%

Cytotoxic Homoisoflavonoids from <i>Ophiopogon japonicus</i> Tubers

Dang

Chung²,

Tuan³

et al. 2017

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…[1] It is always used in stewing fish/chicken and making tea in China. Phytochemical studies have showed that Rhizoma Polygonatum Odorati contains various compounds, such as steroidal saponins, [2,3] homoisoflavonoids [4][5][6][7] polysaccharides, [8][9][10] and cinnamides. [7] Currently, information regarding the bioactivity and pharmacology of Rhizoma Polygonatum Odorati focuses on crude extracts/fractions or single compound with moderate polarities isolated from ethyl acetate fraction.…”

Section: Introductionmentioning

confidence: 99%

Separation of polar antioxidants from Rhizoma Polygonatum Odorati by high-speed counter-current chromatography with a hydrophilic solvent system

Peng

Zhang

Shi

2016

Journal of Liquid Chromatography & Related Technologies

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Some highly polar compounds are quality control makers for medicinal herbs. However, investigation of them has been hampered because the existing fractionation steps are difficult and laborious to purify them. Similar situations happen to Rhizoma Polygonatum Odorati, a widely used food supplement and medicinal herb with strong antioxidant activity, and up to date, only ethyl acetate fraction of Rhizoma Polygonatum Odorati has been comprehensively investigated. Here, HSCCC using a hydrophilic solvent system composed of n-butanol-ethanol-2 M ammonium sulfate (1:1:2, v/v/v) was performed to isolate highly polar antioxidants in n-butanol fraction of Rhizoma Polygonatum Odorati, guided by DPPH-HPLC experiment. Afterward, Sephadex LH-20 column chromatography eluted by methanol was selected to eliminate ammonium sulfate and purify co-eluted compounds in HSCCC collected fractions. Finally, nine compounds, including four nucleosides, cytidine (1), uridine (4), guanosine (5), and adenosine (8); two nucleobases, guanine (3), and adenine (6); and three amino acids, tyrosine (2), phenylalanine (7), and tryptophan (9) with purities over 98% were achieved and identified by UV, MS, and 1 H NMR data. Notably, compounds 1-9 were first reported in genus Polygonatum. The results indicated that the proposed method was an efficient approach to isolate and purify highly polar compounds from complex extracts. GRAPHICAL ABSTRACT

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A dihydrochalcone and several homoisoflavonoids from Polygonatum odoratum are activators of adenosine monophosphate-activated protein kinase

Cited by 46 publications

References 16 publications

Separation and purification of α-glucosidase inhibitors from Polygonatum odoratum by stepwise high-speed counter-current chromatography combined with Sephadex LH-20 chromatography target-guided by ultrafiltration–HPLC screening

Separation and purification of α-glucosidase inhibitors from Polygonatum odoratum by stepwise high-speed counter-current chromatography combined with Sephadex LH-20 chromatography target-guided by ultrafiltration–HPLC screening

Cytotoxic Homoisoflavonoids from <i>Ophiopogon japonicus</i> Tubers

Separation of polar antioxidants from Rhizoma Polygonatum Odorati by high-speed counter-current chromatography with a hydrophilic solvent system

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