A direct assessment of mycotoxin biomarkers in human urine samples by liquid chromatography tandem mass spectrometry

Ediage, Emmanuel Njumbe; Mavungu, José Diana Di; Song, Suquan; Wu, Aibo; Peteghem, Carlos Van; Saeger, Sarah De

doi:10.1016/j.aca.2012.06.038

Cited by 121 publications

(71 citation statements)

References 42 publications

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“…An analysis of 174 cereal-based food products from Belgian supermarkets reported a median of four mycotoxins present in these consumer-available products (De Boevre et al 2012). Population studies of mycotoxin exposure therefore also frequently report detectable amounts of multiple mycotoxins in blood and urine samples from human populations all over the globe (Abia et al 2013;Solfrizzo et al 2014;Shirima et al 2014;Njumbe-Ediage et al 2012). Consequently, an important question remains posed by the current literature, to identify the chronic risks associated with repetitive exposure to low levels of multiple mycotoxins (Warth et al 2013).…”

Section: Co-occurrence and Co-exposure Of Multiple Mycotoxinsmentioning

confidence: 91%

Dietary mycotoxins, co-exposure, and carcinogenesis in humans: Short review

Ruyck

Boevre

Huybrechts

et al. 2015

Mutation Research/Reviews in Mutation Research

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230

148

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Mycotoxins, toxic secondary metabolites of fungi, affect global agriculture so prolifically that they are virtually ubiquitous at some concentration in the average human diet. Studies of in vitro and in vivo toxicity are discussed, leading to investigations of co-exposed mycotoxins, as well as carcinogenic effects. Some of the most common and toxicologically significant mycotoxins, such as the aflatoxins, ochratoxins, fumonisins, deoxynivalenol, T-2 toxin, HT-2 toxin, patulin, zearalenone, and some ergot alkaloids are outlined. The wide variety of pathogenic mechanisms these compounds employ are shown capable of inducing a complex set of interactions. Of particular note are potential synergisms between mycotoxins with regard to carcinogenic attributable risk, indicating an important field for future study.

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Section: Co-occurrence and Co-exposure Of Multiple Mycotoxinsmentioning

confidence: 91%

Dietary mycotoxins, co-exposure, and carcinogenesis in humans: Short review

Ruyck

Boevre

Huybrechts

et al. 2015

Mutation Research/Reviews in Mutation Research

Self Cite

230

148

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“…Therefore it is recommended that levels of aflatoxins should be as low Recently the use of biomarkers in assessing mycotoxin exposure is rapidly becoming a complimentary approach to traditional food analysis Solfrizzo et al, 2011;Turner et al, 2011;Ediage et al, 2012;Warth et al, 2013). However, with the exception of fumonisins biomarker research work that has been carried out in South Africa, comprehensive mycotoxin biomarker exposure assessments in Africa have involved exportation of urine or blood samples to advanced laboratories overseas (Wild et al, 1992;Gong et al, 2004;Ediage et al, 2012;Shephard et al, 2007a. The exportation of specimens may be constrained by ethical challenges and may also not be sustainable in a long-term.…”

Section: Toxicological Data On Mycotoxinsmentioning

confidence: 99%

“…In spite of all these developments at global level, Africa remains constrained with lack of mycotoxin laboratory infrastructure and overall shortage of trained mycotoxicologists and analytical chemists to support the laboratory services. Recently there has been some technological advancement of relatively cheaper, easy-to-use rapid mycotoxins screening kits for use in the field, point of delivery to storage or processing facilities(Ediage et al, 2012;Berthiller et al, 2014;Burmistrova et al, 2014; Dzantiev et al, 2014;Li et al, 2014). However, due to logistical problems (eg transportation) and social-economical factors, such tests are not readily available for use in this part of the world.…”

mentioning

confidence: 97%

Keeping mycotoxins away from the food: Does the existence of regulations have any impact in Africa?

Matumba

Poucke

Ediage

et al. 2015

Critical Reviews in Food Science and Nutrition

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Following the discovery of aflatoxins in the early 1960s, there have been many studies leading to the uncovering of many mycotoxins and the understanding of associated health effects in animals and humans. Consequently, there has been a global increase in the number of countries with mycotoxin regulations in foods. However, many African countries have only regulations for aflatoxins (or a few other mycotoxins) in specific foods, or no regulations at all. This paper critically reviews the challenges thwarting the establishment of mycotoxin regulations and their impacts on human dietary mycotoxin exposure in Africa. Mycotoxin regulatory limits for different countries are compared with mycotoxin tolerable daily intakes established by international food safety bodies taking into account consumption patterns. The agrarian setup, food insecurity, and mycotoxin analytical challenges in African countries are discussed; and more feasible mycotoxin dietary exposure reduction strategies are proposed.

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“…One of the most important aspects in the risk analysis of food contaminants is to determine the degree of human exposure [18]. In the case of mycotoxins, this exposure is generally assessed by taking into account data on mycotoxin occurrence in foodstuffs as well as data on the dietary consumption of the concerned population [19,20], although analytical methods for determination of individual exposure by analysis of biofluids have recently been developed [21,22,23,24]. …”

Section: Introductionmentioning

confidence: 99%

Mycotoxin Contamination in Sugarcane Grass and Juice: First Report on Detection of Multiple Mycotoxins and Exposure Assessment for Aflatoxins B1 and G1 in Humans

Abdallah

Krska

Sulyok

2016

Toxins

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This study was conducted to investigate the natural co-occurrence of multiple toxic fungal and bacterial metabolites in sugarcane grass and juice intended for human consumption in Upper Egypt. Quantification of the target analytes has been done using the “dilute and shoot” approach followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). A total number of 29 and 33 different metabolites were detected in 21 sugarcane grass and 40 juice samples, respectively, with a trend of concentrations being higher in grass than in juice. Among the regulated mycotoxins, only aflatoxin B1 (AFB1) and aflatoxin G1 (AFG1) were detected. The prevalence of AFB1 was in 48% of grass samples and in 58% of juice with a maximum concentration of 30.6 μg/kg and 2.10 μg/kg, respectively. AFG1 was detected in 10% of grass samples (7.76 μg/kg) and 18% of juice samples (34 μg/kg). Dietary exposure was assessed using a juice frequency questionnaire of adult inhabitants in Assiut City. The assessment revealed different levels of exposure to AFB1 between males and females in winter and summer seasons. The estimated seasonal exposure ranged from 0.20 to 0.40 ng/kg b.w./day in winter and from 0.38 to 0.90 ng/kg b.w./day in summer.

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A direct assessment of mycotoxin biomarkers in human urine samples by liquid chromatography tandem mass spectrometry

Cited by 121 publications

References 42 publications

Dietary mycotoxins, co-exposure, and carcinogenesis in humans: Short review

Dietary mycotoxins, co-exposure, and carcinogenesis in humans: Short review

Keeping mycotoxins away from the food: Does the existence of regulations have any impact in Africa?

Mycotoxin Contamination in Sugarcane Grass and Juice: First Report on Detection of Multiple Mycotoxins and Exposure Assessment for Aflatoxins B1 and G1 in Humans

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