A Direct Comparison of Seprafilm, Adept, Intercoat, and Spraygel for Adhesion Prophylaxis

Rajab, Taufiek Konrad; Wallwiener, Markus; Planck, Constanze N. E.; Brochhausen, Christoph; Kraemer, Bernhard; Wallwiener, Christian W.

doi:10.1016/j.jss.2008.11.839

Cited by 72 publications

(64 citation statements)

References 25 publications

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“…Many experimental methods have been used to introduce peritoneal adhesions such as uterine horn cauterization, large bowel anastomosis, ileal transection, peritoneal damage, scraping, and suturing [18,19] . Since scraping is one of the most effective methods for causing adhesions to form, in this study we used this model to evaluate the effects of OT on PPA.…”

Section: Discussionmentioning

confidence: 99%

Uterotonik Bir Ajandan Fazlası: Oksitosin Postoperatif Adezyonları Önlüyor

Işık¹,

Şahbaz²,

Aynıoğlu³

et al. 2016

Kafkas Univ Vet Fak Derg

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Prevention of postoperative adhesions (PPA) has become an important issue. The aim is to investigate the effect of Oxytocin (OT) on PPAs. A total of thirty female Wistar-albino rats were randomly divided into three groups (10 rats/group). The cecal peritone of Group I rats (controls) were scraped, to trigger adhesion formation, and no treatment were given. After cecal scrubbing, 1 mL saline solution was applied to each rat in Group II (i.p. saline treated group) and 80 IU/kg of OT (Pituisan®, Ege Vet, Turkey) to Group III (i.p. OT treated group) intraperitoneally. All animals were sacrificed 10 days after surgery and adhesions graded in terms of severity and histopathologic characteristics. The median scores for the extent, severity, and degree of adhesions in Group I and Group II were statistically significant and considerably higher than those scores for Group III (P<0.001). The inflammation, neovascularization, and fibrosis scores for Group III were statistically significant and considerably lower than those scores for Groups I and II (P<0.001, P<0.001 and P=0.002 respectively). OT, significantly prevented adhesion formation improving wound healing possibly by suppressing adhesion formation with anti-inflammatory and antioxidant properties. OT may be useful in the prevention of PPA in humans.

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Section: Discussionmentioning

confidence: 99%

Uterotonik Bir Ajandan Fazlası: Oksitosin Postoperatif Adezyonları Önlüyor

Işık¹,

Şahbaz²,

Aynıoğlu³

et al. 2016

Kafkas Univ Vet Fak Derg

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“…Günümüzde abdominal/pelvik cerrahide adezyon engelleyici olarak önerilmekte-dir ve klinik çalışmalarda adneksiyal adezyonları önemli ölçüde azalttığı bildirilmektedir. 11,18,19,[23][24][25][26][27][28][29] Daha önceki çalışmalarda PEO+CMS'nin bağır-saklar üzerinde irritan olmadığı ve kuvvetli adezyon önleyici etkiye sahip olduğu gösteril-miştir. 3,11,18,24,26,27 Bizim çalışmamızda da bu maddelerin kuvvetli adezyon önleyici etkisinin olduğu görüldü.…”

Section: Discussionunclassified

Comparison of Substances Used for Prevention of Intra-Abdominal Adhesions: An Experimental Study in Rats

Günaydın¹,

Güvenç²,

Yıldız³

et al. 2012

Turkiye Klinikleri J Med Sci

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Ö ÖZ ZE ET T A Am ma aç ç: : Cerrahi sonrası karın içi yapışıklığı önlemek için şimdiye kadar birçok madde denenmiştir. Bu sorun araştırmacıların önünde bir 'bulmaca' olarak halen durmaktadır. Deneysel ameliyat sonrası yapışıklık modelinde çeşitli yapışıklık önleyici maddeleri karşılaştırmayı amaçladık. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Otuz beş dişi Sprague-Dawley sıçan beş eşit gruba ayrıldı. Laparatomi sonrası, periton ve çekum, nokta nokta kanama görülene kadar diş fırçası ile fırçalandı. Kontrol grubunda (grup 1) ek cerrahi uygulanmadı. Diğer gruplarda, karın içi yapışıklığı önlemek için kanamalı alana sırasıyla polietilenoksid+sodyum-karboksimetilselluloz (PEO+CMS) (grup 2), hyaluronan (HA) (grup 3), oktenidin dihidroklorid+%2 fenoksietanol (ODH+FE) (grup 4) ve surfaktan (SFT) (grup 5) uygulandı. Sıçanlar onuncu günde öldürüldü. Adezyon skorları, fibroblastik akivite ve periserozal inflamasyon skorları ve yüksek performanslı likit kromatografi (HPLC) yöntemiyle hidroksiprolin (HP) düzeyleri belirlendi. B Bu ul lg gu ul la ar r: : Grup 1'in (kontrol) adezyon ve fibroblastik aktivite skorları diğer gruplardan anlamlı ölçüde daha yüksek bulundu (ODH+FE grubu dışında). En düşük adezyon skoru ve hidroksiprolin düzeyi PEO+CMS grubundaydı (p<0,05). En düşük fibroblastik aktivite ve periserozal inflamasyon SFT grubundaydı ve grup 1'den (kontrol) anlamlı derecede farklıydı. ODH grubunda, periserozal inflamasyon diğer gruplardan anlamlı derecede yüksekti (p<0,05). PEO+CMS grubunun adezyon skoru diğer gruplardan anlamlı derecede düşüktü. S So on nu uç ç: : Bu maddelerin hepsinin bir dereceye kadar yapışıklık önleyici etkileri vardır. ODH+FE bağırsak serozasına irritasyon ve zayıf yapışıklık önleyici etkiye sahiptir. SFT bu maddeler arasında en az irritatifti. PEO+CMS en güçlü yapışıklık önleyici madde gibi görülmektedir. Bu çalışma PME+CMS ve HA'nın klinikte kullanımıyla ilgili olumlu raporları desteklemektedir. Özellikle, SFT'nin karın içi yapışıklara karşı etkili olduğu bulundu. Ancak, ODH+FE seyreltilmiş konsantrasyonlarda daha fazla araştırılmalıdır.A An na ah ht ta ar r K Ke el li im me el le er r: : Karın boşluğu; karın ağrısı; doku yapışıklıkları A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Many substances have been used up to date in order to prevent postoperative adhesions. This problem is still a 'puzzle' for researchers. We aimed to compare various substances preventing adhesions in an experimental postoperative adhesion model. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : A total of 35 female Sprague-Dawley rats were divided into five groups containing equal number of animals. After laparatomy, peritoneum and ceacum were brushed using a tooth brush until punctate hemorrhage was seen. Additional surgery was not applied in control group (group 1). In the other groups, polyethylene dioxide+sodium carboxymethyl cellulose (PEO+CMC) (group 2), hyaluronan (HA) (group 3), octenidine dihydrochloride+fenoxyethanol 2% (ODH+FE) (group 4) and surfactant (SFT) (group 5) were...

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“…For the current analysis, experimental adhesions were created bilaterally by an established method [5,6] in n= 11 female, virgin Wistar rats (Crl:WI, Charles River Laboratories, Germany) with a weight range of 220-280 g. This resulted in n=22 scorable adhesion areas. All operations and adhesions were performed by the same surgeons (BK, TR) using powder-free gloves.…”

Section: Operationsmentioning

confidence: 99%

“…Adhesion coverage. This may be calculated as the area covered by adhesions divided by the length of the traumatised area [5,6,9]. Practically, the area coverage can be quantified in situ manually with a measuring stick ( Fig.…”

Section: Operationsmentioning

confidence: 99%

“…There are a myriad of different adhesion-inducing models with subsequent scoring systems descriptively listed in the literature, both macroscopic and microscopic [4]. These aim to describe experiments to improve adhesion barriers [5,6] or optimise surgical instruments with regards to adhesiogenesis. However the lack of uniformity in experimental settings makes the assessment and comparison of adhesion barriers and surgical instruments difficult.…”

Section: Introductionmentioning

confidence: 99%

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Different approaches for objective scoring of experimental post-operative adhesions in the rat model—a description

et al. 2010

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The formation of peritoneal adhesions is an issue for surgical research. Different adhesion-inducing models with subsequent scoring systems are descriptively published. The lack of uniformity is a problem as the reproducibility of experimental adhesion research depends strongly on the employed scoring system. A uniform, widely-used score that seeks to describe this relevant surgical condition would be beneficial for inter-surgeon comparability. We present and contrast six scoring systems after the traumatisation of the parietal peritoneum in the rat model. Advantages, disadvantages and statistical considerations of these systems are highlighted. Experimental adhesions were created bilaterally in n=11 Wistar rats. This resulted in n=22 adhesion areas. Standardised trauma was inflicted to the parietal peritoneum in a linear shape (20×5 mm) using bipolar electrocautery at 40 W. The defect was closed using five interrupted 3/0 Vicryl sutures placed equidistantly. After 14 days, second look laparotomy was performed and number of adhesions, adhesion coverage, adhesion strength, adhesion quality and the attachment to target organs were scored. A total of 43 adhesions formed at the traumatised areas. All of these adhesions could be scored using the six systems described. The correlation coefficient for adhesion coverage as assessed by a measuring stick versus digital computer analysis of the area was 0.649. Every single scoring approach describes different characteristics of adhesions with non-uniform clinical relevance. A multi-dimensional approach that takes account of statistical considerations is inevitable rather than just the use of limited scoring approaches in the experimental setting.

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A Direct Comparison of Seprafilm, Adept, Intercoat, and Spraygel for Adhesion Prophylaxis

Cited by 72 publications

References 25 publications

Uterotonik Bir Ajandan Fazlası: Oksitosin Postoperatif Adezyonları Önlüyor

Uterotonik Bir Ajandan Fazlası: Oksitosin Postoperatif Adezyonları Önlüyor

Comparison of Substances Used for Prevention of Intra-Abdominal Adhesions: An Experimental Study in Rats

Different approaches for objective scoring of experimental post-operative adhesions in the rat model—a description

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