A direct effect of α‐chlorohydrin on rat epididymal spermatozoa

Paz, Gedalia; Homonnai, T. Z.

doi:10.1111/j.1365-2605.1982.tb00259.x

Cited by 20 publications

(6 citation statements)

References 16 publications

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“…The direct effect of a-chlorohydrin on the motility and fertility of rat epididymal spermatozoa in vivo has been confirmed (Chulavatnatol et al 1981;Tsang et al 1981;Paz and Homonnai 1982). Epithelial cells isolated from the caput epididymides of rats treated with a-chlorohydrin (20-73 daily doses of 6-8 mgjkg) showed a 50% decrease in the activity of p-galactosidase, when compared to those from untreated animals, but there was no change in the activities of P-D-glucuronidase or N-acetyl-P-D-glucosaminidase (Kemp and Killian 1978).…”

Section: Effects On the Epididymis Testis And Sperm Of The Ratmentioning

confidence: 90%

Antifertility Actions of a-Chlorohydrin in the Male

Ar¹

1983

Aust. Jnl. Of Bio. Sci.

112

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Non-steroidal chemicals that affect male fertility have been known for over 25 years but only one compound, alpha-chlorohydrin, possesses most of the attributes of an ideal male contraceptive. In the male rat, for example, continuous daily oral administration of low doses produces an almost immediate and continuous antifertility response that ceases when treatment is withdrawn. Such a dose regime does not interfere with libido, is apparently not toxic and the action is specific towards mature sperm. Furthermore, the action of the compound is species-specific: it is effective in the rat, ram, boar, guinea pig, hamster, rhesus monkey and upon ejaculated human sperm but it is ineffective in the mouse and the rabbit. High doses of alpha-chlorohydrin can be neurotoxic, nephrotoxic and, in rats, lead to prolonged or permanent infertility. However, the antifertility response and the toxicity of racemic alpha-chlorohydrin may be due, respectively, to the separate enantiomers. No other antifertility chemical has been investigated to such an extent as alpha-chlorohydrin; this article reviews the progress that has been achieved with alpha-chlorohydrin during the past six years.

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Section: Effects On the Epididymis Testis And Sperm Of The Ratmentioning

confidence: 90%

Antifertility Actions of a-Chlorohydrin in the Male

Ar¹

1983

Aust. Jnl. Of Bio. Sci.

112

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“…B. bengalensis receiving 60 and 70 mg/kg a-CH showed very low percentages of live and motile sperms which revealed the effect of the compound at the cauda epididymis level. Earlier, Paz & Homonnai (1982) also observed a marked decrease in sperm concentration and sperm motility following continuous administration of a-CH (20 mg daily) for 16 days to the laboratory rats. Results of their in uitro and in uiuo studies clearly showed that the fertilising capacity of the spermatozoa was greatly reduced at low motility; fertility was 0% at about 13% sperm motility.…”

Section: Results a N D Discussionmentioning

confidence: 65%

Laboratory evaluation of a toxicant‐sterilant, alpha‐chlorohydrin, for the control of Indian mole rat Bandicota bengalensis

Saini

Parshad

1988

Annals of Applied Biology

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A toxicant-sterilant, alpha-chlorohydrin, was evaluated against the Indian mole rat Bandicora bengalensis and the ship or house rat Ratrus raftus. It caused 100% mortality of B. bengalensis at 100 mg/kg but no mortality was observed in R. rattus even at 300mg/kg. The acute oral LDS0 for B. bengalensis was found to be 82 mg/kg. The survivors of B. bengalensis, which received 60 -90 mg/kg of alphachlorohydrin by oral intubation, showed dose-dependent decreases in testicular weight, and cauda epididymal sperm concentration, live sperm count and sperm motility. The values of these parameters indicated that mole rats receiving the above doses would be sterile. In contrast, these changes were observed in R. rattus only at doses of 200 and 300 mg/kg. The toxic and antifertility effects of alphachlorohydrin observed on B. bengalensis suggest that it should be evaluated for the management of this species under field conditions.

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“…The antifertility effects of -chlorohydrin, which reduces sperm motion, are well-known (Coppla, 1969;Samojlik and Chang, 1970;Vickery et al, 1974;Paz and Homonnai, 1982;Yamada et al, 1995). We analyzed sperm of rats administered -chlorohydrin with the CellSoft-4000 in a collaborative study (Ban et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Investigation of usefulness of sperm analyses in dogs for male fertility study.

et al. 2001

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The usefulness of sperm analyses in dogs, including sperm motion analysis, was investigated. Sperm motion analysis was performed with the CellSoft-4000 computer-assisted sperm analysis (CASA) system. First, we examined the conditions for preservation of optimal semen quality. We found that sperm retained more of their motility at 4 than at 37 . Secondly, we observed sperm motion, concentration and morphology in dog semen continuously for 11 weeks. We collected semen samples during the test period, and the samples retained sperm motion, concentration and morphology. Finally, we administrated -chlorohydrin, which decreases rodent sperm motion, at a single oral dose of 100 mg/kg or 150 mg/kg to dogs. Sperm motion was inhibited immediately after -chlorohydrin treatment, and recovered after 2 weeks. None of the experimental animals were sacrificed in the above-mentioned examinations.We thus confirmed that sperm analyses including motion analysis in dogs are useful in male fertility studies.

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A direct effect of α‐chlorohydrin on rat epididymal spermatozoa

Cited by 20 publications

References 16 publications

Antifertility Actions of a-Chlorohydrin in the Male

Antifertility Actions of a-Chlorohydrin in the Male

Laboratory evaluation of a toxicant‐sterilant, alpha‐chlorohydrin, for the control of Indian mole rat Bandicota bengalensis

Investigation of usefulness of sperm analyses in dogs for male fertility study.

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