In the context of hybrid formulations, the Poincaré-Steklov operator acting on traces of solutions to the vector Helmholtz equation in a heterogeneous interior domain with a smooth boundary is regularized by a well-known boundary integral operator related to the homogeneous exterior domain. For the first time, this property allows us to simultaneously construct a Calderón multiplicative preconditioner for the discretized operator and for a 3-D hybrid finite/boundary element method formulation, applicable to electromagnetic scattering problems. Numerical examples demonstrate the effectiveness of this novel preconditioning scheme, even for heterogeneous domains with non-smooth boundaries.