“…In recent years, data-knowledge-driven approaches have attracted increasing attention and interest in academia and have achieved the broad applications in solving various engineering problems such as system modeling and control, process monitoring, fault diagnosis, and so on. − Specifically, as an important artificial intelligence (AI) technique, the Bayesian network (BN) is a type of probabilistic graphical model that is capable of effectively integrating data and knowledge to simulate human reasoning. It represents the causal relations of variables by a directed acyclic graph, and so it has better interpretability than other AI methods. , Owing to the advantages in interpretability, probabilistic modeling, and dealing with data uncertainties, BNs have been widely applied to a variety of industrial systems and processes in different areas to successfully solve problems such as process monitoring, fault diagnosis, prognosis, risk assessment, decision making, etc. ,, However, the BN-based PQC studies in the pharmaceutical field are rarely reported. Because of its significant advantages and application potential, we attempt to utilize BN for PQC (or operational adjustment) tasks for the first time.…”