A disaccharide repeat unit is the major structure in fucoidans from two species of brown algae

Chevolot, Lionel; Mulloy, Barbara; Ratiskol, Jacqueline; Foucault, Alain; Colliec-Jouault, Sylvia

doi:10.1016/s0008-6215(00)00314-1

Cited by 264 publications

(163 citation statements)

References 17 publications

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“…Xylans and ulvans were investigated from P. palmata (Turvey and Williams 1970;Deniaud, Quemener et al 2003) and U. lactuca (Lahaye, Jegou et al 1994;Siddhanta 2001), respectively. A number of studies have reported on fucoidans and other sulfated fucans from A. nodosum and F. vesiculosus (Chevolot, Mulloy et al 2001;Usov and Bilan 2009). …”

Section: Structural Feature Analysismentioning

confidence: 99%

Properties of polysaccharides in several seaweeds from Atlantic Canada and their potential anti-influenza viral activities

Jiao

Wang

et al. 2012

J. Ocean Univ. China

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Objective: To explore the polysaccharides from selected seaweeds of Atlantic Canada and to evaluate their potential anti-influenza virus activities. Methods: Polysaccharides were isolated from several Atlantic Canadian seaweeds, including three red algae (Polysiphonia lanosa, Furcellaria lumbricalis, and Palmaria palmata), two brown algae (Ascophyllum nodosum and Fucus vesiculosus), and one green alga (Ulva lactuca) by sequential extraction with cold water, hot water, and different alkali solutions. These polysaccharides were analyzed for monosaccharide composition and other general  First author: Guangling Jiao, Ph.D candidate, Glycochemistry and glycobiology, Email: sebrina2006@gmail.com;  Corresponding author: Guangli Yu, Professor, Glycochemistry and glycobiology, E-Mail: glyu@ouc.edu.cn. chemical properties, and they were evaluated for anti-influenza virus activities. Results:Total sugar contents in these polysaccharides ranged from 15.4 % (in U. lactuca) to 91.4 % (in F. lumbricalis); sulfation level was as high as 17.6 % in a polysaccharide from U. lactuca whereas it couldn't be detected in an alikali-extract from P. palmaria. For polysaccharides extracted from red seaweeds, the main polysaccharides were sulfated agar and carrageenan for P. lanosa, F. lumbricalis, and xylans for P. palmata. In brown seaweeds, the polysaccharides mainly contained sulfated fucans, whereas the polysaccharides in green seaweeds were composed of heteroglycuronans. Screening for antiviral activity against influenza A/PR/8/34 (H1N1) virus revealed that brown algal polysaccharides were particularly effective. Conclusion: Seaweeds from Atlantic Canada are a good source of marine polysaccharides with potential antiviral properties.

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Section: Structural Feature Analysismentioning

confidence: 99%

Properties of polysaccharides in several seaweeds from Atlantic Canada and their potential anti-influenza viral activities

Jiao

Wang

et al. 2012

J. Ocean Univ. China

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“…Green and red algae also contain sulfated galactans that involve many pathophysiological systems. These sulfated glycans occur as structural components in the cell walls of algae (Chevolot et al, 2001), and their structures are maintained among phyla. Most sulfated glycans found in algae are composed of disaccharide repeating units with distinct sulfation patterns.…”

Section: Discussionmentioning

confidence: 99%

Detection of a Non-animal Source of Glycosaminoglycans from Edible Mushrooms in Northern Thailand

Choocheep¹,

Nathip²

2018

CMUJNS

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Several kinds of cultivated or local edible mushrooms exist in northern Thailand. While their nutritional features have been extensively analyzed, the presence of phytochemicals and glycosaminoglycans has yet to be investigated. Thus, in this study, we examined the presence of phytochemicals and glycosaminoglycans from 10 cultivated or local mushrooms: milk white russula, hygroscopic earthstar, log white fungi, log black fungi, shitake mushroom, rosy russula, sajor-caju mushroom, Jew's ear, bolete, and straw mushroom. Phytochemical analysis revealed the presence of carbohydrates, amino acids, and flavonoids in the extracts from most of the mushrooms. We detected glycosaminoglycans in all of the extracts using dimethylmethylene blue (DMMB) dye-binding assay and UVVis spectrophotometry. Hygroscopic earthstar contained the most glycosaminoglycans and sajor-caju mushroom the least. However, we were unable to distinguish the types of glycosaminoglycans, which should be considered for future study. In summary, the phytochemicals found here are crucial non-animal dietary sources of carbohydrates, amino acids, and antioxidants. In addition, the glycosaminoglycans detected in the mushroom extracts in this study potentially offer a non-animal source of glycosaminoglycans that may have clinical applications, apart from their nutritive value.

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“…A disaccharide repeating unit of a LMW fucoidan isolated from Ascophylum nodosum prepared by acid hydrolysis and partition chromatography [9] The structures of algal fucoidans are usually complicated, because they are heterogeneous and branched with nonregular sulfation patterns, and may contain additional monosaccharide constituents or acetyl groups [8]. Nontheless, Chevolot and his team [9] have succeeded in isolating a disaccharide repeating structure of a low molecular weight fraction of the fucoidan from Ascophylum nodosum prepared by acid hydrolysis and partition chromatography, as shown in Fig.1:…”

Section: Figmentioning

confidence: 99%

“…Nontheless, Chevolot and his team [9] have succeeded in isolating a disaccharide repeating structure of a low molecular weight fraction of the fucoidan from Ascophylum nodosum prepared by acid hydrolysis and partition chromatography, as shown in Fig.1:…”

Section: Figmentioning

confidence: 99%

Studies on Fucoidan and Its Production From Vietnamese Brown Seaweeds

Lý¹,

Buu²,

Nhut³

et al. 2017

AJSTD

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Sulfated fucans are among the most widely studied of all the sulfated polysaccharides of plant origin that exhibit biological activities in mammalian systems. In this report fucoidans from some Vietnamese Sargassum species such as S. polycystum, S. oligocystum, S. mcclurei, S. swartzii and denticaprum were extracted and fractionated on a DEAE-Sephadex A-25 column.On the basis of chemical and spectral analyses, the fucoidan fractions obtained were found to be the sulfated fucogalactans containing sulfate ester groups and uronic acid, and composed essentially of fucose and galactose, as well as a minor amount of other sugars. The polysaccharide fractions were tested for anticancer activity. The primarily obtained results showed that all fucoidan fractions isolated from S. swartzii demonstrate bioactivity effects against cancer cells, while fraction F5 with a highest sulfate content exhibits the strongest antiinvasion activity. This indicates that sulfate content plays an important role in the anticancer activity of the brown algal fucoidans.A laboratory scale pilot for fucoidan production from Vietnamese brown seaweeds has been set with a capacity of 500 g of crude fucoidan per day.

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A disaccharide repeat unit is the major structure in fucoidans from two species of brown algae

Cited by 264 publications

References 17 publications

Properties of polysaccharides in several seaweeds from Atlantic Canada and their potential anti-influenza viral activities

Properties of polysaccharides in several seaweeds from Atlantic Canada and their potential anti-influenza viral activities

Detection of a Non-animal Source of Glycosaminoglycans from Edible Mushrooms in Northern Thailand

Studies on Fucoidan and Its Production From Vietnamese Brown Seaweeds

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