A discourse: The 2002 Wataru W. Sutow lecture Hodgkin disease in children—perspectives and progress

Donaldson, Sarah S.

doi:10.1002/mpo.10219

Cited by 12 publications

(5 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The long-term survival of patients after the treatment of childhood cancer, especially Hodgkin`s diesease (HD), has greatly improved in the last few decades due to the effective treatment, especially multiagent chemotherapy (ChT) 1. The chief concern is now being directed toward the late effects of the treatment2, which influence on patient’s quality of life and become more and more important in cancer treatment 3,4.…”

Section: Introductionmentioning

confidence: 99%

Gonadal function in patients treated for Hodgkin's disease in childhood

Zaletel¹,

Bratanič²,

Jereb³

2010

Radiology and Oncology

View full text Add to dashboard Cite

BackgroundThe long-term survival of patients treated for Hodgkin`s disease (HD) in childhood is high and the chief concern is now being directed toward the late effects of the treatment, including the endocrine dysfunction.Patients and methods.Testicular and ovarian functions were assessed in 64 long term survivors (24 females, 40 males) treated for HD in childhood in Slovenia between 1972 and 1994. At diagnosis they were 3–16 years old and had gonadal evaluation 4–27 years later at the age of 13–34. Fifty-four (84%) patients received chemotherapy (ChT), 49 in combination with radiation therapy (RT), 10 received RT alone. Gonadal function was assessed by the clinical examination and measurement of serum concentrations of estradiol and testosterone. Serum levels of LH and FSH were determined in the basal state and after the stimulation.ResultsPrimary hypogonadism (PH) was found in 30 (47%) patients. Twenty-four of 40 (60%) males had PH with evidence of damage of germinal epithelium, 4 of them had evidence of damage of Leydig cells (LC) and 10 had evidence of dysfunction of LC as well. PH was found in 6 of 24 (25%) females.ConclusionsAfter therapy for HD PH was more frequent in males than in females. Not only RT but also alkylating agents and procarbazine alone caused damage of LC. Age of patient at the time of treatment was not an important risk factor for gonadal toxicity. Pelvic RT in combination with ChT is the most important risk factor of the development PH both, in males and females.

show abstract

Section: Introductionmentioning

confidence: 99%

Gonadal function in patients treated for Hodgkin's disease in childhood

Zaletel¹,

Bratanič²,

Jereb³

2010

Radiology and Oncology

View full text Add to dashboard Cite

show abstract

“…Therefore the main objective of new pediatric studies is to reduce treatment‐related early and late effects while maintaining high survival rates. Since prognosis is affected by interaction between tumor and host prognostic factors reflecting these interactions may predict the clinical outcome of a patient 1–3.…”

Section: Introductionmentioning

confidence: 99%

Prognostic factors and treatment outcome in childhood hodgkin disease

Oğuz

Karadeniz

Okur

et al. 2005

Pediatric Blood & Cancer

View full text Add to dashboard Cite

show abstract

“…The duration of our schedule is not much longer than the schedules‐combined modalities—recently reviewed by Donaldson 39, except the DAL‐HD‐90 multicenter trial 41 with limited CT to two cycles for stage I and IIA. The schedules of CT alone of the Amsterdam group 15 and the Australian group 16 also takes 6 months.…”

Section: Discussionmentioning

confidence: 99%