Background: Globally, 358,000 women die during pregnancy and childbirth every year. Poor skilled delivery health care uptake remains a significant problem in developing countries. In Ethiopia, skilled delivery care service uptake was law. Marginalized women are vulnerable for poor delivery care uptake and addressing woman’s’ social marginalization could play an important role in increasing uptake of skilled delivery care service among minorities in the study area. Thu, the study was aimed to access the utilization of delivery care uptake and associated factors among women from socially marginalized minorities in the Kambeta-Temabaro, Zone Southern Ethiopia. Methods: Community based cross-sectional study was conducted from April 01 to March 30, 2019. Multistage sampling procedure was employed to enroll 521 study participants. An interviewer administered questionnaire was used to collect the data. Data was entered using EPI- INFO and exported to Statistical Package for Social Science (SPSS)-21 for analysis. The degree of association was assessed using odds ratio with 95% confidence interval and the variable with p-value <0.05 were declared as statistically significant. The model fitness was checked using Pearson’s Chi-square with the value of 3.45 and significance 0.026 Result: The magnitude of skilled delivery care service uptake among socially marginalized minorities was 19% in the study area. Maternal education, occupation, and awareness on delivery care, pregnancy plan, and number of birth, mothers’ life-style, and social discrimination were significantly associated with the delivery care service uptake among women from socially marginalized minorities. Conclusion: The prevalence of the delivery service utilization among marginalized mothers was found to be low [19%]. Mothers’ education, occupation, life-style, awareness, number of birth and social discrimination was significantly associated with delivery service uptake from health facilities in Kambata-Tembaro zone, Southern Ethiopia. Thus, intervention on social discrimination in the community to breakthrough core barriers; improving women awareness though health education and promotion; and accessing education and employment for women are highly recommended.