A discrete role for FNR in the transcriptional response to moderate changes in oxygen by Haemophilus influenzae Rd KW20

Jiang, Donald; Tikhomirova, Alexandra; Bent, Stephen J.; Kidd, Stephen P.

doi:10.1016/j.resmic.2015.09.008

Cited by 2 publications

(1 citation statement)

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“…Fnr is essentially present in the apo-form (clusterless) in aerobically grown cells, and in the holo-form in anaerobically grown cells ( Esbelin et al, 2012 ). Under aerobiosis, Fnr is able to sense oxygen concentration changing and probably ROS and NO ( Jiang et al, 2016 ) through the oxidation of Cys thiol groups, which link two monomers in an inactive dimer. The inactivation of Fnr by oxygen is reversible.…”

Section: Oxygen Sensing and Adaptation To Anoxiamentioning

confidence: 99%

Adaptation in Bacillus cereus: From Stress to Disease

2016

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Bacillus cereus is a food-borne pathogen that causes diarrheal disease in humans. After ingestion, B. cereus experiences in the human gastro-intestinal tract abiotic physical variables encountered in food, such as acidic pH in the stomach and changing oxygen conditions in the human intestine. B. cereus responds to environmental changing conditions (stress) by reversibly adjusting its physiology to maximize resource utilization while maintaining structural and genetic integrity by repairing and minimizing damage to cellular infrastructure. As reviewed in this article, B. cereus adapts to acidic pH and changing oxygen conditions through diverse regulatory mechanisms and then exploits its metabolic flexibility to grow and produce enterotoxins. We then focus on the intricate link between metabolism, redox homeostasis, and enterotoxins, which are recognized as important contributors of food-borne disease.

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Section: Oxygen Sensing and Adaptation To Anoxiamentioning

confidence: 99%

Adaptation in Bacillus cereus: From Stress to Disease

2016

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Synthesis of Super-High-Viscosity Poly-γ-Glutamic Acid by pgdS-Deficient Strain of Bacillus licheniformis and Its Application in Microalgae Harvesting

Zhang,

Wu,

Mou

et al. 2024

Microorganisms

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Poly-γ-glutamic acid (γ-PGA) is a natural polymer whose molecular weight and viscosity are critical for its application in various fields. However, research on super-high-molecular-weight or -viscosity γ-PGA is limited. In this study, the pgdS gene in Bacillus licheniformis WX-02 was knocked out using homologous recombination, and the batch fermentation performances of the recombinant strain WX-ΔpgdS were compared to those of WX-02. Nitrate accumulation was observed in the early fermentation stages of WX-ΔpgdS, and gene transcription analysis and cell morphology observations revealed that nitrite accumulation was caused by oxygen limitation due to cell aggregation. When the aeration and agitation rates were increased to 2.5 vvm and 600 r/min, respectively, and citrate was used as a precursor, nitrite accumulation was alleviated in WX-ΔpgdS fermentation broth, while γ-PGA yield and broth viscosity reached 17.3 g/L and 4988 mPa·s. Scanning electron microscopy (SEM) showed that the γ-PGA produced by WX-ΔpgdS exhibited a three-dimensional porous network structure. At a γ-PGA concentration of 5 mg/L, the fermentation broth of WX-ΔpgdS achieved a flocculation efficiency of 95.7% after 30 min of microalgae settling. These findings demonstrate that pgdS knockout results in super-high-viscosity γ-PGA, positioning it as an eco-friendly and cost-effective biocoagulant for microalgae harvesting.

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A discrete role for FNR in the transcriptional response to moderate changes in oxygen by Haemophilus influenzae Rd KW20

Cited by 2 publications

References 36 publications

Adaptation in Bacillus cereus: From Stress to Disease

Adaptation in Bacillus cereus: From Stress to Disease

Synthesis of Super-High-Viscosity Poly-γ-Glutamic Acid by pgdS-Deficient Strain of Bacillus licheniformis and Its Application in Microalgae Harvesting

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