A Discussion of the Current Limitations of Diabetes Etiology

Abstract

The Biology of Diabetes The first step to consider in the process of Diabetes (DM) is that of genetic expression in which a wide spectrum of genes, currently considered to be more than 60 genes [1], coherently interact in order to express pre-pro-insulin (type 1 diabetes) however the interpretation of such data is complicated when considering that the spectrum of genes which express pre-pro-insulin can differ [2] e.g. between different racial subtypes. There are few instances, if any, where a single gene acts independently of all other genes in order to express a particular protein or where a single gene is considered to be responsible for a particular medical indication e.g. in the case of Rett's syndrome [3], which is considered to be widely attributable to a single mutation in the MECP2 gene, a more in-depth examination of the literature reveals a lack of certainty surrounding such a conclusion e.g. • 'Mutations in a gene called MECP2 underlie almost all cases of classic Rett syndrome' • 'Using a systematic gene screening approach, we have identified mutations in the gene (MECP2) encoding X-linked methyl-CpG-binding protein 2 (MeCP2) as the cause of some cases of RTT'. • 'In 5 of 21 sporadic patients, we found 3 de novo missense mutations in the region encoding the highly conserved