A disintegrin and metalloprotease-10 is correlated with disease activity and mediates monocyte migration and adhesion in rheumatoid arthritis

Isozaki, Takeo; Ishii, Sho; Nishimi, Shinichiro; Nishimi, Airi; Oguro, Nao; Seki, S.; Miura, Yoko; Miwa, Yusuke; Oh, Koei; Toyoshima, Yoichiro; Nakamura, Masanori; Inagaki, Kenji; Kasama, Tsuyoshi

doi:10.1016/j.trsl.2015.02.005

Cited by 16 publications

(18 citation statements)

References 34 publications

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“…Indeed, the putative substrates of ADAM9, ADAM10 and ADAM17 identified by MS in CSF fluid, according to MEROPS, include amyloid beta A4 protein (Table S1, Supporting Information), supporting its involvement in AD pathogenesis. These ADAM proteases were already assessed in body fluids, mostly in blood‐derived ones, with ELISA approaches, and related with other pathological conditions besides AD …”

Section: Comparative Analysis Of Proteases Distribution Among Distincmentioning

confidence: 99%

Reviewing Mechanistic Peptidomics in Body Fluids Focusing on Proteases

et al. 2018

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The comprehension of how protease networks sculpt proteomes might help to disclose the functional annotation of the peptidome in health and disease. Envisioning to add new insights on the protease networks involved in the regulation of body fluid peptidomes, the authors apply Proteasix software to predict the proteases involved in the generation of the naturally occurring peptides present in six of the most studied human body fluids. Peptidome data is collected from the databases and from experimental studies. The analysis highlights 132 putative proteases from four families with the predominance of serine proteases and metalloproteases. From these, 49 proteases seem to be common to all fluids and are mostly associated to extracellular matrix organization as well as protein/peptide hormone processing. Data analysis also emphasizes: i) the similarity between plasma and CSF protease profiles; ii) that saliva and tears share proteases involved in the generation of peptides with antimicrobial activity; iii) that urine is the body fluid with the highest number of unique putative proteases, precluding an easy tracing of proteolytic events in this case. Taken together, the analysis emphasizes the intricate modus operandi of proteases, challenged by the interconnected pathways and amplification cascades in which they are involved.

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Section: Comparative Analysis Of Proteases Distribution Among Distincmentioning

confidence: 99%

Reviewing Mechanistic Peptidomics in Body Fluids Focusing on Proteases

et al. 2018

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“…ADAM (a disintegrin and metalloproteases) is a family of proteases that release a variety of membrane proteins; it has been reported that ADAM-10 is responsible for releasing different chemokines, like CXCL16 and CX3CL1 [55]. Isozaki et al in 2015 reported that the levels of ADAM-10 in serum from RA patients were significantly higher compared to healthy controls by ELISA; this correlated with the disease activity measured by DAS28 (disease activity score of 28).…”

Section: Endothelial Alterations In Sle and Ra: Potential Contribumentioning

confidence: 99%

“…These findings were corroborated with the fibroblast-like synoviocytes from patients, which were transfected with specific siRNA (small interfering RNA) to ADAM-10 transcription; the silencing of this gene in vitro inhibited the monocyte and synoviocyte adhesion to the endothelial cells and decreased growth factor and production of CX3CL1. These results suggest that ADAM-10 plays an important role in the monocyte adhesion to inflamed tissues from RA patients and that it could be involved in the endothelial alteration of these patients [55]. …”

Section: Endothelial Alterations In Sle and Ra: Potential Contribumentioning

confidence: 99%

Endothelial Alterations in Systemic Lupus Erythematosus and Rheumatoid Arthritis: Potential Effect of Monocyte Interaction

Atehortúa

Rojas

Vásquez

et al. 2017

Mediators of Inflammation

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Patients with systemic autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are prone to develop atherosclerosis and cardiovascular diseases five times more often than the general population; this increase in frequency could be partially explained by an increase in the macrovasculature endothelial damage. In these autoimmune diseases, a microvascular endothelial injury has also been reported in different organs and tissues, especially in sites where ultrafiltration processes occur. Different components that are characteristic to the immunopathology of RA and SLE could be involved in the endothelial cell activation, permeability increase, functional alteration, and vascular injury. Circulating immune complexes (IC) detected in SLE and RA have been proposed to participate in the endothelial injury. In the vascular environment, IC can generate different responses that could be mediated by monocytes, because these cells have patrolling and monitoring functions on the endothelium. However, with certain stimuli such as TLR ligands, the monocytes are retained in the lumen, releasing proinflammatory mediators that participate in the endothelial damage. This paper aims to review some aspects about the endothelial activation and dysfunction in the context of SLE and RA, as well as the potential role that monocytes apparently play in this process.

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“…ADAM10 is also overexpressed in the synovial tissue of RA patients (95). It has been reported that ADAM10 is correlated with disease activity and regulates monocyte migration and adhesion in RA patient fluids (96,97). ADAM10 elevation in specific cells or tissues correlates strongly with various disease states.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies demonstrate that ADAM10 is upregulated in endothelial cells and synovial lining fibroblasts in RA tissue biopsies compared to osteoarthritis and healthy patients (95). Additionally, in vitro studies reveal that siRNA knockdown of ADAM10 impairs angiogenesis and suppresses VEGF release in endothelial cell lines (95,96). Administration of this siRNA in vivo in a murine model of collagen-induced arthritis improved arthritis symptoms and reduced serum levels of the angiogenic cytokine VEGF (97).…”

Section: Rheumatoid Arthritismentioning

confidence: 99%