A Disintegrin and Metalloproteases (ADAMs): Activation, Regulation and Mechanisms of Catalysis

Maretzky, Thorsten

doi:10.3390/ijms22168762

IJMS

2021

DOI: 10.3390/ijms22168762

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A Disintegrin and Metalloproteases (ADAMs): Activation, Regulation and Mechanisms of Catalysis

Thorsten Maretzky

Abstract: In the late 1980s, Paul Primakoff and colleagues showed that fertilization could be blocked in an in vitro sperm–egg fusion assay by inoculating them in the presence of a disintegrin and metalloprotease (ADAM)-specific antibody [...]

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Metalloproteinases in dermal homeostasis

Kümper

Steinkamp

Zigrino

2022

American Journal of Physiology-Cell Physiology

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Maintenance of skin homeostasis is a highly regulated and complex process involving a continuous remodeling by several extracellular matrix proteases, including metalloproteinases. The expression and activity of all metalloproteinases are under strict control, and their deregulation is often associated with diseases or chronic conditions, thereby being considered popular targets for developing new therapeutics. This review will highlight metalloproteinases of the MMP and ADAM families with functions in dermal homeostasis and give some insights into the mechanisms regulating their activity and expression. Further, we discuss how the dysregulation of the most prominent family members affects dermal homeostasis by triggering disease development and influencing progression, focusing on cancer and aging. Here, recent discoveries and new approaches that target or exploit metalloproteinase activity in therapy are emphasized. The potential of naturally derived components in regulating metalloproteinase expression and activity in disease is discussed.

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Metalloproteinases in dermal homeostasis

Kümper

Steinkamp

Zigrino

2022

American Journal of Physiology-Cell Physiology

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show abstract

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A Disintegrin and Metalloproteases (ADAMs): Activation, Regulation and Mechanisms of Catalysis

Abstract: In the late 1980s, Paul Primakoff and colleagues showed that fertilization could be blocked in an in vitro sperm–egg fusion assay by inoculating them in the presence of a disintegrin and metalloprotease (ADAM)-specific antibody [...]

Cited by 1 publication

References 19 publications

Metalloproteinases in dermal homeostasis

Metalloproteinases in dermal homeostasis

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