A Disintegrin and Metalloproteinase (ADAM) and ADAM with thrombospondin motifs (ADAMTS) family in vascular biology and disease

Zhong, Sheng; Khalil, Raouf A.

doi:10.1016/j.bcp.2019.03.033

Cited by 84 publications

(60 citation statements)

References 201 publications

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“…In addition to the established role of MMPs in myocardial ECM turnover, emerging evidence implicates two other families of proteases, the ADAM (A Disintegrin and Metalloproteinase), and the ADAMTS (ADAM with Thrombospondin Motifs) 183 , 184 . ADAM and ADAMTS family members can be activated in response to a wide range of stimuli and have multiple substrates.…”

Section: The Role Of Ecm Metabolism In Regulation Of Geometry and Funmentioning

confidence: 99%

The Extracellular Matrix in Ischemic and Nonischemic Heart Failure

Frangogiannis

2019

Circulation Research

374

287

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The ECM (extracellular matrix) network plays a crucial role in cardiac homeostasis, not only by providing structural support, but also by facilitating force transmission, and by transducing key signals to cardiomyocytes, vascular cells, and interstitial cells. Changes in the profile and biochemistry of the ECM may be critically implicated in the pathogenesis of both heart failure with reduced ejection fraction and heart failure with preserved ejection fraction. The patterns of molecular and biochemical ECM alterations in failing hearts are dependent on the type of underlying injury. Pressure overload triggers early activation of a matrix-synthetic program in cardiac fibroblasts, inducing myofibroblast conversion, and stimulating synthesis of both structural and matricellular ECM proteins. Expansion of the cardiac ECM may increase myocardial stiffness promoting diastolic dysfunction. Cardiomyocytes, vascular cells and immune cells, activated through mechanosensitive pathways or neurohumoral mediators may play a critical role in fibroblast activation through secretion of cytokines and growth factors. Sustained pressure overload leads to dilative remodeling and systolic dysfunction that may be mediated by changes in the interstitial protease/antiprotease balance. On the other hand, ischemic injury causes dynamic changes in the cardiac ECM that contribute to regulation of inflammation and repair and may mediate adverse cardiac remodeling. In other pathophysiologic conditions, such as volume overload, diabetes mellitus, and obesity, the cell biological effectors mediating ECM remodeling are poorly understood and the molecular links between the primary insult and the changes in the matrix environment are unknown. This review article discusses the role of ECM macromolecules in heart failure, focusing on both structural ECM proteins (such as fibrillar and nonfibrillar collagens), and specialized injury-associated matrix macromolecules (such as fibronectin and matricellular proteins). Understanding the role of the ECM in heart failure may identify therapeutic targets to reduce geometric remodeling, to attenuate cardiomyocyte dysfunction, and even to promote myocardial regeneration.

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Section: The Role Of Ecm Metabolism In Regulation Of Geometry and Funmentioning

confidence: 99%

The Extracellular Matrix in Ischemic and Nonischemic Heart Failure

Frangogiannis

2019

Circulation Research

374

287

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“…71,72 For example, trabodenoson, an adenosine mimetic with A1 selectivity, has been shown to increase MMP-2 activity and decrease fibronectin and collagen IV levels in 3-dimensional human TM cell cultures and has also been shown to increase outflow facility and lower IOP in young and aged mice. 72 In addition, the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of extracellular proteases, related to the MMP family, also remodels the ECM, 73 and treatment with recombinant ADAMTS-4 has been shown to increase outflow facility in cultured porcine and human anterior segments. 74 ADAMTSs potentially could be involved in the mechanism of IOP lowering by PGAs downstream of MMP upregulation, as MMP-17 has been shown to activate ADAMTS-4.…”

Section: Cynomolgus Monkeysmentioning

confidence: 99%

Matrix Metalloproteinases and Glaucoma Treatment

Weinreb

Robinson

Dibas

et al. 2020

Journal of Ocular Pharmacology and Therapeutics

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Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade extracellular matrix (ECM) components such as collagen and have important roles in multiple biological processes, including development and tissue remodeling, both in health and disease. The activity of MMPs is influenced by the expression of MMPs and tissue inhibitors of metalloproteinase (TIMPs). In the eye, MMP-mediated ECM turnover in the juxtacanalicular region of the trabecular meshwork (TM) reduces outflow resistance in the conventional outflow pathway and helps maintain intraocular pressure (IOP) homeostasis. An imbalance in the MMP/TIMP ratio may be involved in the elevated IOP often associated with glaucoma. The prostaglandin analog/prostamide (PGA) class of topical ocular hypotensive medications used in glaucoma treatment reduces IOP by increasing outflow through both conventional and unconventional (uveoscleral) outflow pathways. Evidence from in vivo and in vitro studies using animal models and anterior segment explant and cell cultures indicates that the mechanism of IOP lowering by PGAs involves increased MMP expression in the TM and ciliary body, leading to tissue remodeling that enhances conventional and unconventional outflow. PGA effects on MMP expression are dependent on the identity and concentration of the PGA. An intracameral sustained-release PGA implant (Bimatoprost SR) in development for glaucoma treatment can reduce IOP for many months after expected intraocular drug bioavailability. We hypothesize that the higher concentrations of bimatoprost achieved in ocular outflow tissues with the implant produce greater MMP upregulation and more extensive, sustained MMP-mediated target tissue remodeling, providing an extended duration of effect. IOP, intraocular pressure; MMP, matrix metalloproteinase; MT-MMP, membrane-type MMP; TIMP, tissue inhibitor of metalloproteinase.MMPS AND GLAUCOMA TREATMENT 209 210 WEINREB ET AL.

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“…ADAMTS20 belongs to the ADAMTS (a disintegrin and metallopeptidase with thrombospondin motifs) proteins family, which is a secretory metalloproteinase (Hubmacher & Apte, 2015). ADAMTS proteins generally contain multiple domains including a metalloproteinase domain and a disintegrin domain, which could both have an important impact on the extracellular matrix (ECM) (Rivera et al, 2019;Zhang et al, 2019b;Zhong & Khalil, 2019). ECM participates in cell proliferation, differentiation, and migration, and then regulates chicken growth and development (Iyoda & Fukai, 2012;Katayama et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Peer Review #2 of "Transcriptome for the breast muscle of Jinghai yellow chicken at early growth stages (v0.1)"

2020

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Background: The meat quality of yellow feathered broilers is better than the quality of its production. Growth traits are important in the broiler industry. The exploration of regulation mechanisms for the skeletal muscle would help to increase the growth performance of chickens. At present, some progress has been made by researchers, but the molecular mechanisms of the skeletal muscle still remain unclear and need to be improved. Methods: In this study, the breast muscles of fast-and slow-growing female Jinghai yellow chickens (F4F, F8F, F4S, F8S) and slow-growing male Jinghai yellow chickens (M4S, M8S) aged four and eight weeks were selected for transcriptome sequencing (RNAseq). All analyses of differentially expressed genes (DEGs) and functional enrichment were performed. Finally, we selected nine DEGs to verify the accuracy of the sequencing by qPCR. Results: The differential gene expression analysis resulted in 364, 219 and 111 DEGs (adjusted P-value ≤0.05) for the three comparison groups, F8FvsF4F, F8SvsF4S, and M8SvsM4S, respectively. Three common DEGs (ADAMTS20, ARHGAP19, and Novel00254) were found , and they were all highly expressed at four weeks of age. In addition, some other genes related to growth and development, such as ANXA1, COL1A1, MYH15, TGFB3 and ACTC1, were obtained. The most common DEGs (n =58) were found between the two comparison groups F8FvsF4F and F8SvsF4S, and they might play important roles in the growth of female chickens. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway also showed some significant enrichment pathways, for instance, extracellular matrix (ECM)-receptor interaction, focal adhesion, cell cycle, and DNA replication. The two pathways that were significantly enriched in the F8FvsF4F group were all contained in that of F8SvsF4S. The same two pathways were ECM-receptor interaction and focal adhesion, and they had great influence on the growth of chickens. However, many differences existed between male and female chickens in regards to common DEGs and KEGG pathways. The results would help to reveal the regulation mechanism of the growth and

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A Disintegrin and Metalloproteinase (ADAM) and ADAM with thrombospondin motifs (ADAMTS) family in vascular biology and disease

Cited by 84 publications

References 201 publications

The Extracellular Matrix in Ischemic and Nonischemic Heart Failure

The Extracellular Matrix in Ischemic and Nonischemic Heart Failure

Matrix Metalloproteinases and Glaucoma Treatment

Peer Review #2 of "Transcriptome for the breast muscle of Jinghai yellow chicken at early growth stages (v0.1)"

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