A disposable electrochemical sensor based on single-walled carbon nanotubes for the determination of anticancer drug dasatinib

Abstract

Dasatinib is an anticancer drug that treats acute lymphoblastic leukemia, chronic myelogenous leukemia, and prostate cancer with several side effects. In this research, we suggest nanoparticle-modified screen-printed electrodes (SPCEs) as disposable electrochemical sensors for fast quantification of dasatinib in pharmaceutical formulations. Carbon nanotubes, single-walled carbon nanotubes (SWCNT), graphene, and graphene oxide-modified SPCEs were characterized by scanning electron microscopy. The study also recommends SWCNT-modified SPCEs as the best-performing electrode for determining dasatinib, demonstrating an excellent boosting effect on the oxidation response of dasatinib. This was accomplished using the square-wave voltammetry method. After optimization of the pH condition, pH 5.0 Britton–Robinson buffer, SWCNT-modified SPCEs demonstrated 94% recovery with optimum electro-oxidation activity. The oxidation currents exhibited linear relation with dasatinib concentration in the 0.1–100 µM. Based on the results, a limit of detection of 0.06 µM was obtained in the standard solution. The SWCNT-modified SPCEs have been applied to analyze dasatinib in pharmaceutical tablet samples. The demonstrated performance beats all comparable standard analytical tools and presumably may be used for general drug quantitation in pharmaceutical tablets. Graphical abstract

Porous Zinc Oxide and Functionalized Multiwalled Carbon Nanotubes Composite as Electrode Material for Enhanced Electrochemical Sensing of an Anticancer Drug, Dasatinib

“…Some functionalized materials such as SWCNT and Fe 3 O 4 -SWCNTs/ionic liquid, were used to modify the electrode surface and proposed the detection of DAS. 23,24 Since then, carbonbased materials have garnered much attention in various fields due to their exceptional conductivity, high specific surface area and unique electrical and catalytic capabilities. 25 As a unique carbon material, z E-mail: drjseetharamapp@kud.ac.in MWCNTs have extensive applications, particularly in the field of electrochemical sensing, due to their high specific surface area, good electrical conductivity, high porosity, and hollow structure.…”