A disposable piezoelectric micropump with high performance for closed-loop insulin therapy system

Drug delivery systems play a crucial role in the treatment and management of medical conditions. Microelectromechanical systems (MEMS) technologies have allowed the development of advanced miniaturized devices for medical and biological applications. This Review presents the use of MEMS technologies to produce drug delivery devices detailing the delivery mechanisms, device formats employed, and various biomedical applications. The integration of dosing control systems, examples of commercially available microtechnology-enabled drug delivery devices, remaining challenges, and future outlook are also discussed.

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“…[ 55 ] This pump consisted of four chambers in serial connection. The pump was made out of biocompatible Reprinted with permission.…”

Section: Piezoelectricmentioning

confidence: 99%

MEMS: Enabled Drug Delivery Systems

Cobo

Sheybani

Meng

2015

Adv Healthcare Materials

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“…It has a wide range of application and broad prospects in the industries such as biomedical science, fine chemicals, fuel feeding and household appliance. [1][2][3][4] However, in the commercialization of the piezoelectric pump, there are still many difficulties yet to be solved. One of the main problems encountered is that the piezoelectric pump is extremely sensitive to air bubbles.…”

Section: Introductionmentioning

confidence: 99%

The effect of surface wettability on the performance of a piezoelectric membrane pump

et al. 2018

Self Cite

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In this paper, we studied the effect of surface wettability on the bubble tolerance of a piezoelectric membrane pump, by applying the super-hydrophilic or super-hydrophobic surface to the key elements on the pump. Wettability for the flow passage surface has a direct influence on the air bubbles flowing in the fluid. Based on the existing research results, we first analyzed the relationship between the flow passage surface of the piezoelectric pump and the bubbles in the fluid. Then we made three prototypes where pump chamber walls and valve plate surfaces were given different wettability treatments. After the output performance test, results demonstrate that giving super-hydrophilic treatment on the surface of key elements can improve the bubble tolerance of piezoelectric pump; in contrast, giving super-hydrophobic treatment will reduce the bubble tolerance.

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“…Piezoelectric (PZT) pumps, self‐priming diaphragm micropumps that are compact, lightweight, easy to use, and allow low‐cost fluid delivery, are now the dominant pump in drug delivery systems and other biomedical applications . Although PZT micropumps can pump both liquid and gas , they are normally used to transport liquids through a pump chamber.…”

Section: Introductionmentioning

confidence: 99%

A compact and facile microfluidic droplet creation device using a piezoelectric diaphragm micropump for droplet digital PCR platforms

et al. 2017

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We have exploited a compact and facile microfluidic droplet creation device consisting of a poly(dimethylsiloxane) microfluidic chip possessing T-junction channel geometry, two inlet reservoirs, and one outlet reservoir, and a piezoelectric (PZT) diaphragm micropump with controller. Air was evacuated from the outlet reservoir using the PZT pump, reducing the pressure inside. The reduced pressure within the outlet reservoir pulled oil and aqueous solution preloaded in the inlet reservoirs into the microchannels, which then merged at the T-junction, successfully forming water-in-oil emulsion droplets at a rate of ∼1000 per second with minimal sample loss. We confirmed that the onset of droplet formation occurred immediately after turning on the pump (<1 s). Over repeated runs, droplet formation was highly reproducible, with droplet size purity (polydispersity, <4%) comparable to that achieved using other microfluidic droplet preparation techniques. We also demonstrated single-molecule PCR amplification in the created droplets, suggesting that the device could be used for effective droplet digital PCR platforms in most laboratories without requiring great expense, space, or time for acquiring technical skills.

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A disposable piezoelectric micropump with high performance for closed-loop insulin therapy system

Cited by 71 publications

References 21 publications

MEMS: Enabled Drug Delivery Systems

MEMS: Enabled Drug Delivery Systems

The effect of surface wettability on the performance of a piezoelectric membrane pump

A compact and facile microfluidic droplet creation device using a piezoelectric diaphragm micropump for droplet digital PCR platforms

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