A Distinct Neurophenotype of Fearful Face Processing in Alcohol Use Disorder With and Without Comorbid Anxiety

MacIlvane, Nicole M.; Fede, Samantha J.; Pearson, Emma E.; Diazgranados, Nancy; Momenan, Reza

doi:10.1111/acer.14465

Cited by 2 publications

(4 citation statements)

References 97 publications

(103 reference statements)

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“…For studies with more than one comparison group, 38 – 49 we report any significant findings between the substance use group and one of the control groups. One study in the reward domain examined twin pairs discordant for cigarette smoking.…”

Section: Resultsmentioning

confidence: 87%

“…One study in the negative emotionality domain included three groups, ie, individuals with co-occurring alcohol use disorder (AUD)+Anxiety, individuals with AUD-Anxiety, and healthy controls. 39 To prevent introducing a confound of psychiatric illness in our review, we excluded the findings between the AUD + Anxiety group and the other two groups. Thus, we present only findings from the AUD-Anxiety versus healthy control groups.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Functional Domains of Substance Use and their Implications to Trauma: A Systematic Review of Neuroimaging Studies

Hinojosa,

Sitar,

Zhao

et al. 2024

Chronic Stress

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Substance use disorder (SUD) is a significant health problem, and trauma exposure is a known risk factor for the escalation of substance use. However, the shared neural mechanisms through which trauma is associated with substance use are still unknown. Therefore, we systematically review neuroimaging studies focusing on three domains that may contribute to the overlapping mechanisms of SUD and trauma—reward salience, negative emotionality, and inhibition. Using PRISMA guidelines, we identified 45 studies utilizing tasks measuring these domains in alcohol, tobacco, and cannabis use groups. Greater reward, lesser regulation of inhibitory processes, and mixed findings of negative emotionality processes in individuals who use substances versus controls were found. Specifically, greater orbitofrontal cortex, ventral tegmental area, striatum, amygdala, and hippocampal activation was found in response to reward-related tasks, and reduced activation was found in the inferior frontal gyrus and hippocampus in response to inhibition-related tasks. Importantly, no studies in trauma-exposed individuals met our review criteria. Future studies examining the role of trauma-related factors are needed, and more studies should explore inhibition- and negative-emotionality domains in individuals who use substances to uncover clinically significant alterations in these domains that place an individual at greater risk for developing a SUD.

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Section: Resultsmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 99%

Functional Domains of Substance Use and their Implications to Trauma: A Systematic Review of Neuroimaging Studies

Hinojosa,

Sitar,

Zhao

et al. 2024

Chronic Stress

View full text Add to dashboard Cite

show abstract

“…For this study, we chose the comparison of individuals who regularly smoked versus those who did not regularly smoke but not their cotwins. One study in the negative emotionality domain included three groups, i.e., individuals with co-occurring alcohol use disorder (AUD)+Anxiety, individuals with AUD-Anxiety, and healthy controls (MacIlvane et al, 2020). To prevent introducing a confound of psychiatric illness in our review, we excluded the findings between the AUD+Anxiety group and the other two groups.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…To prevent introducing a confound of psychiatric illness in our review, we excluded the findings between the AUD+Anxiety group and the other two groups. Thus, we present only findings from the AUD-Anxiety versus healthy control groups (MacIlvane et al, 2020).…”

Section: Study Characteristicsmentioning

confidence: 99%

Functional Domains of Substance Use and Trauma: A Systematic Review of Neuroimaging Studies

Sitar

Zhao

Barbosa

et al. 2023

Preprint

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In a framework for substance use concerning trauma, Hien and colleagues suggested three domains: reward salience, executive function, and negative emotionality. In this PRISMA-guided systematic review, we explored the neural correlates of these domains in individuals who use substances with or without trauma exposure. We included 45 studies utilizing tasks of interest in alcohol, tobacco, and cannabis use groups. Greater reward, lesser regulation of inhibitory processes, and mixed findings of negative emotionality processes in individuals who use substances versus controls were found. Specifically, greater orbitofrontal cortex, ventral tegmental area, striatum, amygdala, and hippocampal activation was found in response to reward-related tasks, and reduced activation was found in the inferior frontal gyrus and hippocampus in response to inhibition-related tasks. No studies in trauma-exposed individuals met our review criteria. Future studies examining the role of trauma-related factors are needed and should explore inhibition- and negative-emotionality domains in individuals who use substances to uncover alterations in these domains that place an individual at greater risk for developing SUD.

show abstract

A Distinct Neurophenotype of Fearful Face Processing in Alcohol Use Disorder With and Without Comorbid Anxiety

Cited by 2 publications

References 97 publications

Functional Domains of Substance Use and their Implications to Trauma: A Systematic Review of Neuroimaging Studies

Functional Domains of Substance Use and their Implications to Trauma: A Systematic Review of Neuroimaging Studies

Functional Domains of Substance Use and Trauma: A Systematic Review of Neuroimaging Studies

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