A distinct par polarity protein complex physically associated with VE-cadherin in vertebrate endothelial cells

Iden, Sandra; Rehder, Daniela; August, Benjamin K.; Suzuki, Atsushi; Noda, Kazuhiko; Behrens, Juergen; Vestweber, Dietmar; Ebnet, Klaus

doi:10.1016/j.vph.2006.08.228

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2012

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“…The following antibodies were used in this study: rabbit polyclonal antibodies directed against Par3 aa712-936 (Iden et al, 2006) and commercial sources (Millipore/Upstate, no. 07-330, and SIGMA-Aldrich HPA030443), aPKCzeta (C-20, Santa Cruz), PARP (no.…”

Section: Antibodiesmentioning

confidence: 99%

Tumor Type-Dependent Function of the Par3 Polarity Protein in Skin Tumorigenesis

et al. 2012

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Cell polarization is crucial during development and tissue homeostasis and is regulated by conserved proteins of the Scribble, Crumbs, and Par complexes. In mouse skin tumorigenesis, Par3 deficiency results in reduced papilloma formation and growth. Par3 mediates its tumor-promoting activity through regulation of growth and survival, since Par3 deletion increases apoptosis and reduces growth in vivo and in vitro. In contrast, Par3-deficient mice are predisposed to formation of keratoacanthomas, cutaneous tumors thought to originate from different cellular origin and frequently observed in humans. Par3 expression is reduced in both mouse and human keratoacanthomas, indicating tumor-suppressive properties of Par3. Our results identify a dual function of Par3 in skin cancer, with both pro-oncogenic and tumor-suppressive activity depending on the tumor type.

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Section: Antibodiesmentioning

confidence: 99%