A distinct subset of urothelial cells with enhanced EMT features promotes chemotherapy resistance and cancer recurrence by increasing COL4A1-ITGB1 mediated angiogenesis

Guo, Jinan; Ma, Xiaoshi; Liu, Dongcheng; Wang, Fei; Xia, Jinquan; Zhang, Bin; Zhao, Pan; Zhong, Fuhua; Chen, Lipeng; Long, Qiaoyun; Jiang, Lu; Zhang, Siyu; Liao, Naikai; Wang, Jigang; Wu, Weiqing; Sun, Jichao; Huang, Mou; Cheng, Zhiqiang; Huang, Guixiao; Zou, Chang

doi:10.1016/j.drup.2024.101116

Drug Resistance Updates

2024

DOI: 10.1016/j.drup.2024.101116

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A distinct subset of urothelial cells with enhanced EMT features promotes chemotherapy resistance and cancer recurrence by increasing COL4A1-ITGB1 mediated angiogenesis

Jinan Guo,

Xiaoshi Ma,

Dongcheng Liu

et al.

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Cited by 2 publications

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Harnessing natural inhibitors of protein synthesis for cancer therapy: A comprehensive review

Liu,

Li,

2024

Pharmacological Research

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Harnessing natural inhibitors of protein synthesis for cancer therapy: A comprehensive review

Liu,

Li,

2024

Pharmacological Research

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The Multifaced Role of Collagen in Cancer Development and Progression

Lo Buglio,

Lo Cicero,

Campora

et al. 2024

IJMS

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Collagen is a crucial protein in the extracellular matrix (ECM) essential for preserving tissue architecture and supporting crucial cellular functions like proliferation and differentiation. There are twenty-eight identified types of collagen, which are further divided into different subgroups. This protein plays a critical role in regulating tissue homeostasis. However, in solid tumors, the balance can be disrupted, due to an abundance of collagen in the tumor microenvironment, which significantly affects tumor growth, cell invasion, and metastasis. It is important to investigate the specific types of collagens in cancer ECM and their distinct roles in tumor progression to comprehend their unique contribution to tumor behavior. The diverse pathophysiological functions of different collagen types in cancers illustrate collagen’s dual roles, offering potential therapeutic options and serving as prognostic markers.

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A distinct subset of urothelial cells with enhanced EMT features promotes chemotherapy resistance and cancer recurrence by increasing COL4A1-ITGB1 mediated angiogenesis

Cited by 2 publications

References 73 publications

Harnessing natural inhibitors of protein synthesis for cancer therapy: A comprehensive review

Harnessing natural inhibitors of protein synthesis for cancer therapy: A comprehensive review

The Multifaced Role of Collagen in Cancer Development and Progression

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